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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From Jan, 1975 to Nov, 1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: reliable with restriction. well documented. Not according to GLP nor to specific test guideline
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Routine patch testing with cadmium chloride
Author:
Wahlberg JE
Year:
1977
Bibliographic source:
Cont. Dermat. 3(6):293-296

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
Human patch test
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
CdCl2

Method

Type of population:
general
Subjects:
- Number of subjects exposed: 1502
- Sex: M + F
- Age: 24-68 y
- Known diseases: Eczema
Ethical approval:
not specified
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
measured
Details on exposure:
2% CdCl2 solution, serial dilutions: 1%-0.5%-0.06%
Examinations:
skin allergy
Medical treatment:
not applicable

Results and discussion

Clinical signs:
- 25 of 1502 eczema patients showed skin reactions (1.7%)
Results of examinations:
skin irritation
Effectivity of medical treatment:
not applicable
Outcome of incidence:
- 25 of 1502 eczema patients showed skin reactions (1.7 %) with 2% CdCl2
- At serial dilution test: only one patient reacted to 1% CdCl2; all the other dilutions applied gave negative reactions
- No certain case of contact allergy to CdCl2 has been revealed

Any other information on results incl. tables

none                     

Applicant's summary and conclusion

Conclusions:
No conclusive case of contact allergy to cadmium chloride has been found in this study.
Executive summary:

During a 22-month period, 2.0 % cadmium chloride in distilled water was included in routine patch test series. Twenty-five of 1502 eczema patients showed reactions (1.7 %), but none had any relevant history. At serial dilution test only one patient reacted to 1.0% cadmium; all the other dilutions applied gave negative reactions. Analysis by atomic absorption spectrophotometry of the cadmium chloride used for patch testing showed that it contained less than 1 µg/g of chromium, copper, cobalt and nickel. The conclusion is that no certain case of contact allergy to cadmium chloride has been revealed. An experimental study using the guinea pig maximization test is in progress.