Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-135-5 | CAS number: 7440-25-7
An experimental study was performed to determine the fate and metabolism of inhaled tantalum to dogs. During the study, dogs were insufflated with powdered tantalum and its retention and clearance monitored with bronchograms and roentgenograms.
Under the conditions of the study, tantalum was not found to cause unfavourable tissue reaction. When inhaled, there was no evidence of either acute or chronic inflammatory response in the airways or pulmonary tissue. Powdered tantalum delivered to the large airways was carried up the airways and cleared by ciliary activity and by coughing within 4 days. Some of this tantalum was swallowed and excreted. The tantalum reaching the gastrointestinal tract produced no untoward effects.
Thus it was found that tantalum in the conducting airways was completely eliminated without significant inflammatory effects or absorption. Tantalum delivered to peripheral airways was cleared slowly via phagocytosis. During the phagocytic process, no evidence of fibroblastic or inflammatory response in the pulmonary tissue was noted. Thus it was found that modes of lung clearance of tantalum depend on deposition. Neither airways nor lung parenchyma showed adverse responses to tantalum.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again