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Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

N2O is not an irritant gas.


Whilst both skin and eye irritation data for N2O are lacking, no significant signs of either eye or skin irritation have been reported in the animal experiments. The wealth of human data in the public domain (EIGA 2008, EHC 1997, HSDB 2011, IPCS 1992) have reported no significant signs of irritation to the skin or eye. 



- European Health Criteria (EHC) (1997). Nitrogen oxides (2ndedition). United Nations Environmental Programme. International Labour Organisation. World Health Organisation. International Programme on Chemical Safety.

- European Industrial Gases Association (EIGA) (2008). Review of toxicological data on nitrous oxide. MGC 153/08/E. Prepared by P. Branptom.

- HSDB (2011). Nitrous oxide. Hazardous Substances Data Bank.

- International Programme on Chemical Safety (IPCS) INCHEM (1992). Nitrous oxide. PIM 381.

- National library of medicine HSDB database on nitrous oxide (CASRN: 10024-97-2) retrieved 4 August 2011.

Justification for classification or non-classification

Skin irritation: no classification required. 


Eye irritation: no classification required.