Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-807-2 | CAS number: 88-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Several reliable (Klimisch 1 or 2) toxicity studies in fish, invertebrates, and algae have been conducted for o-tert-butylphenol and are included in this dossier. Additionally, reliable toxicity studies with fish, invertebrates, algae, and microorganisms with the structural analogue, o-sec-butylphenol, have been included for supporting evidence. There were no reliable measured data for long-term toxicity to fish, however, modelled data are presented.
Reliable (Klimisch 1 or 2) short-term toxicity studies with fish have been conducted for o-tert-butylphenol and the structural analogue, o-sec-butylphenol and are included in this dossier.
The key study,Sasol (2013), provides a 96-hr LC50 of 2.682 mg/L for fish for o-tert-butylphenol
No reliable long-term toxicity studies with fish are available for o-tert-butylphenol. However modeled data are available and included in the dossier. Sasol (2013) provided a reliable (Klimisch 2) study for o-tert-butylphenol using the QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program to estimate long-term toxicity to fish. The ECOSAR model estimates aquatic toxicity based on the structural similarity to chemicals for which aquatic studies are available.In addition, the log Kow and molecular weight of o-tert-butylphenol are within the criteria (max log Kow = 7 for acute, 8 for chronic and max molecular weight = 1000) and domain of the model.The measured log Kow of 3.3 was used in the model. Model results indicate a 30 day chronic value (the geometric mean of the NOEC and LOEC) to be 0.327 mg/L for phenol. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC = 0.231 mg/L for the phenol category and consequently will be taken for the long-term toxicity to fish endpoint.
Reliable (Klimisch 2) short-term toxicity studies with invertebrates have been conducted for o-tert-butylphenol or the structural analogue, o -sec-butylphenol
and are included in this dossier. The key study, Schulz (1995), provides a 48-hr EC50 of 3.4 mg/L for o-tert-butylphenol for Daphnia magna. Additionally, McLeese et al (1981) provides a 96 -hr EC50 of 2.4 mg/L for o-tert-butylphenol for the saltwater shrimp. Consequently, these values will be taken as the short-term toxicity in aquatic invertebrates endpoint for o-tert-butylphenol.Japan MOE (1999) conducted a reliable (Klimisch 1) GLP compliant long-term toxicity test following OECD 211 methods. Daphnia magna were exposed to measured concentrations of 0.0032, 0.01, 0.032, 0.1, 0.32, 1.0, and 3.2 mg/L of o-sec-butylphenol. The 21-day NOEC based on reproduction was 0.32 mg/L. Consequently this value will be taken as the long-term toxicity in aquatic invertebrates endpoint for o-tert-butylphenol.
Adequate reliable measured data exists for toxicity to algae to o-tert-butylphenol and the analogue, o-sec-butylphenol. The data point of highest concern for this endpoint has been identified in a reliable study which reports a measured 72 hr EC50 of 6.5 mg/L and 72 hr EC10 of 2.0 mg/L, based on growth, for toxicity to aquatic algae. Consequently these values will be taken as the toxicity in aquatic algae endpoint for o-tert-butylphenol.
Horton et al. (1991) conducted a reliable study on the toxicity of the analogue, o-sec-butylphenol, to activated sludge microorganisms following OECD 209 guidelines. Activated sludge microorganisms were exposed to a control and 10 mg/L of the test substance for 3 hrs. Oxygen consumption was measured to determine the 3 hr EC50 of > 10 mg/L. Consequently, this value will be taken to fulfill the toxicity to microorganisms endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
