Registration Dossier
Registration Dossier
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EC number: 292-603-2 | CAS number: 90640-81-6 The anthracene-rich solid obtained by the crystallization and centrifuging of anthracene oil. It is composed primarily of anthracene, carbazole and phenanthrene.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
For anthracene oil containing less than 50 ppm of BaP (structure-related to anthracene paste), weakly mutagenic potential may be observed in vitro:
An Ames test in the presence of metabolising enzymes was positive only in TA 100 at cytotoxic concentrations;
A mouse-lymphoma assay (MLA, OECD 476) was weakly positive for the closely structure-related tar oil creosote;
A cytogenetic assay (chromosomal aberration, OECD 473) came out negative for the very same tar oil.
An in-vivo micronucleus test in mice using creosote gave no evidence of a mutagenic potential.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The slight mutagenic potential eventually detected in in-vitro standard assays conducted with structure-related tar oils containing BaP levels of =< 50 ppm has not been confirmed in an in vivo mammalian erythrocyte micronucleus assay.
Taking into account the combined evidence of all the tests performed, the overall mutagenicity potential should be evaluated negative. Annthracene paste (BaP =< 50 ppm) is supposed to reflect similar mutagenic properties.
Thus, classification according to Regulation (EC) No 1272/2008 or Directive (EU) 67/548/EEC is not required.
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