Registration Dossier
Registration Dossier
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EC number: 202-196-5 | CAS number: 92-84-2
Endpoint summary
Administrative data
Description of key information
Additional information
Relevant factors for phenothiazine are the low water solubility and vapour pressure, its moderate Kow and Koc and its known photo-instability. In a test for ready biodegradability no microbial breakdown of the substance was observed.
No bioaccumulation is expected as the log Kow is 3.78. The actual ECHA Guidance as well as the most recent ECETOC-Report state, that a Log Kow < 4.5 is a definitive indicator for non B/vB properties in aquatic systems. According to the ECHA Guidance the uptake of an organic substance is driven by its hydrophobicity. For organic substances with a log Kow value below 4.5 it is assumed that the affinity for the lipids of an organism is insufficient to exceed the B criterion, i.e. a BCF value of 2000 L/kg.
This is supported by the Japanese bioaccumulation study cited in this dossier, in which the applicants come to the conclusion, that phenothiazine is determinated to be non or not highly bioaccumulative. Additionally this is supported by calculations with the EPI-Suite 4.11 software (BCFBAF 3.01).
According to ECHA Guidance all available relevant information (testing data and non-testing information) should be taken into account, incl. toxicokinetics studies with mammals.
There are several studies on the metabolism and the toxicokinetics of phenothiazine in mammals and man, e.g. the study cited in section 7.1.1. According to this study, in man phenothiazine and/or it´s metabolites are excreted totally via faeces and urine within 5 days. This is supported by an older review of the same author (Mitchell et. al., Drug Metabolism Reviews, 13(2), 319-343 (1982)). In this review it is shown, that phenothiazine and/or its metabolites are excreted via the urine and faeces, even so, depending on the species, it may take days or week for nearly total elimination. From this studies it can be concluded, that bioaccumulation in terrestrial animals can be considered to be not relevant.
Therefore a further vertebrate study on the bioaccumulation potential of the substance can not be recommended.
In conclusion, transport through air is no matter of concern and the only affected compartment are sediments in the aquatic environment. As the substance did not show any microbial degradation, phenothiazine is considered to be persistent.
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