Registration Dossier
Registration Dossier
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EC number: 272-810-4 | CAS number: 68915-38-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1947
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, short documentation, purity not specified, reliability of detection method unclear
Data source
Reference
- Reference Type:
- publication
- Title:
- Die Bernsteinsaeureausscheidung bei Stoffwechselbelastung mit hoeheren n-Dicarbonsaeuren.
- Author:
- Weitzel G (1947).
- Year:
- 1 947
- Bibliographic source:
- Hoppe-Seylers Z. physiol. Chemie 282, 185-191.
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- Adipic acid was orally administered to 4 different humans to investigate the excretion of this compound. Urine was collected and the adipic acid concentration analyzed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- Hexanedioic Acid
- Details on test material:
- IUCLID4 Test substance: purity not specified
Constituent 1
Test animals
- Species:
- human
Results and discussion
Main ADME results
- Type:
- excretion
- Results:
- Adipic acid is readily excreted in urine, unchanged.
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Test no.:
- #1
- Toxicokinetic parameters:
- other: One Person (70 kg) received 7 g adipic acid per day (100 mg/kg bw/day) over 10 days (70 g in total) given in several portions over the day. Urine was collected for these 10 days and two additional days after end of administration. 61% of the administere
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
One Person (70 kg) received 7 g adipic acid per day (100 mg/kg bw/day) over 10 days (70 g in total) given in several portions over the day. Urine was collected for these 10 days and two additional days after end of administration. 61% of the administered dose was found in the urine. Three further persons received 23.4, 19.0, and 23.4 g adipic acid over 6, 5, and 9 days, respectively. 53% of the administered dose was found in the urine. No symptoms were reported during and after exposure.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Adipic acid is readily excreted in urine, unchanged.
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