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EC number: 907-131-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Followed the specific protocol and standard protocol amendment by the Bushy Run Research Center. Five Sprague-Dawley rats per sex per dose were exposed to the aerolised test substance via a whole body inhalation system. They were exposed to a dose of 5.2 mg/L air for 4 hours. After an observation period of 14 days animals wer necropsied.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-(ethylenedioxy)diethanol
- EC Number:
- 203-953-2
- EC Name:
- 2,2'-(ethylenedioxy)diethanol
- Cas Number:
- 112-27-6
- Molecular formula:
- C6H14O4
- IUPAC Name:
- 2,2'-[ethane-1,2-diylbis(oxy)]diethanol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Source: Union Carbide Chemicals and Plastics Company Inc., Texas City, TX
- Purity: ≥ 99.7%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague-Dawley Inc., Indianapolis, IN
- Housing: Rats were housed 5 per sex in stainless steel, wire-mesh cages in 2 rooms for the prestudy quarantine and postexposure periods, respectively. During exposure, rats were housed individually in 21 x 12.5 x 18 cm wire-mesh cages and exposed in a 1300-liter Plexiglas and stainless steel chamber
- Diet: Pelletal feed (Pro Lab RMH #3000, Agway, Inc.), ad libitum, except during exposure
- Water: tap water, ad libitum, except during exposure
ENVIRONMENTAL CONDITIONS
- Temperature: 19-23 °C
- Humidity: 40-56%
- Photoperiod: 12/12 h
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- 5.54 µm
- Geometric standard deviation (GSD):
- 2.71
- Remark on MMAD/GSD:
- MMAD 95% confidence interval were 4.72 - 6.50 µm
- Details on inhalation exposure:
- The test substance was metered from a piston pump (Fluid Metering Inc., Oyster Bay, NY) into an atomizer (Spraying Systems Co., Wheaton, IL) fitted with a No. 1650 liquid nozzle and a No. 64 air nozzle. The atomizer was positioned in the top of the inhalation chamber turret where the liquid diluted to the desired concentration and dispersed throughout the chamber by filtered supply air.
The target concentration for the exposure was 5 mg/L, based on the guidelines for "limit" testing met forth by the Toxic Substances Control Act (TSCA). A particle size lower than an MMAD of 5.3 µm could not be produced without greatly reducing the aerosol concentration of the test substance. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.2 mg/L air
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Animals were observed for signs of toxic effects on the day of exposure and daily following exposure. The animals were weighed prior to exposure and postexposure Days 7 and 14. The change in body weight was calculated by subtracting the pre-exposure values from each successive weight. A complete necropsy was performed for all animals. The survivors were anaesthesized with methoxyflurane and killed by exsanguination via the brachial blood vessels. No tissues were saved.
- Statistics:
- The mean and standard deviation of the body weights, body weight changes, and exposure concentrations were calculated. No statistical comparisons were made.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Periocular wetness, blepharospasm wet (oily fur), absence of toe and tail pinch reflexes. Unkempt fur was the only sign observed during the post-exposure period.
- Gross pathology:
- No macroscopic lesions were observed in animals sacrificed at the end of the 2-week post-exposure period.
Any other information on results incl. tables
A mean (+/- SD) of the test substance concentration of 5.23 (±0.15) mg/L was obtained. The nominal concentration was 19.3 mg/L.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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