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EC number: 907-131-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The substance is not considered to be irritating the skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Additional information is available in the endpoint summaries and the read-across justification (see section 13).
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- other: Results from read-across CAS No. 112-60-7.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 15 min
- Score:
- 0
- Remarks on result:
- other: Results from read-across CAS No. 112-60-7.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Remarks on result:
- other: Results from read-across CAS No. 112-60-7.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Additional information is available in the endpoint summaries and the read-across justification (see section 13).
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 days
- Score:
- 0
- Remarks on result:
- other: Result from read-across CAS No. 112-60-7.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are no studies available that evaluate the skin and/or eye irritating potential of the substance itself (target, EC 907-131-0). Therefore studies from a structural analogue (TetraEG, CAS 112-60-7) has been used to cover this endpoint.
Skin irritation / corrosion
In a pre-GLP toxicity study, skin irritation potential of TetraEG was assessed with two Vienna-White rabbits. The intact or abraded skin (clipped) of the animals was exposed to 0.5 g of the test substance on an area of 2.5 cm² under occlusive conditions for 20 hours (BASF, 1976). Animals were observed for 8 days. Findings were recorded after 1 min, 5 min, 15 min and 20 hours and at the end of the observation period. After 20-hour exposure a slight reddening (ear) was observed, which was reversible within 8 days. As the overall irritation score was determined to be 0, the substance is not considered to be irritating to the skin.
In a pre-GLP toxicity study, skin irritation potential of TetraEG was assessed with two rabbits. The skin of the animals was exposed to the test substance under occlusive conditions for 20 hours (BASF, 1964). Readings were performed after 24 hours and 8 days. After 20-hour exposure questionable reddening was observed, which was reversible within 8 days. As the overall irritation score was determined to be 0, the substance is not considered to be irritating to the skin.
As TetraEG (CAS 112-60-7) was not considered to be irritating to the skin, the target substance (EC 907-131-0) was also not considered to be irritating to the skin.
Eye irritation
In a pre-GLP toxicity study, eye irritation potential was assessed with two Vienna White rabbits. Animals were exposed to 0.05 mL of TetraEG for 24 hours (BASF, 1976). The untreated eye served as a control. Eyes were examined 1 hour, 24 hours and 8 days after instillation. After 1 and 24 hours, slight reddening was observed, which fully reversed after 8 days. Under the conditions of the test, the test substance was not considered irritating to eyes.
In a pre-GLP toxicity study, eye irritation potential was assessed with two rabbits. Animals were exposed to TetraEG for 24 hours (BASF, 1964). The untreated eye served as a control. Eyes were examined 1 hour, 24 hours and 8 days after instillation. After 1 hour, slight reddening was observed, which fully reversed after 24 hours. Under the conditions of the test, the test substance was not considered irritating to eyes.
As TetraEG (CAS 112-60-7) was not considered to be irritating to the eyes, the target substance (EC 907-131-0) was also not considered to be irritating to the eyes.
Justification for classification or non-classification
Based on the results of the skin and eye irritation tests, the substance does not have to be classified for skin or eye irritation in accordance with Regulation (EC) No. 1272/2008. However, since the substance (EC 907-131-0) contains up to 3% potassium hydroxide (CAS: 1310-58-3) impurity, the test substance has to be classified as Skin Corr. 1B (H314) and Eye Dam. 1 according to the harmonised classification and labelling.
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