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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
According to BASF-internal standards.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,6,9-trioxaundecane-1,11-diol
EC Number:
203-989-9
EC Name:
3,6,9-trioxaundecane-1,11-diol
Cas Number:
112-60-7
Molecular formula:
C8H18O5
IUPAC Name:
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
Test material form:
liquid
Specific details on test material used for the study:
- Purity: about 90%

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
Body weight male rabbit: 3.48 kg
Body weight female rabbit: 3.49 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact or abraded
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
20 h
Observation period:
Readings after 24 hours and 8 days
Number of animals:
2
Details on study design:
The test substance was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 20 h under occlusive conditions. The skin was either intact or abraded. After the application time, the skin was washed with water which may have contained a mild detergent. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 1 min, 5 min, 15 min and 20 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
0
Irritant / corrosive response data:
After 20-hour exposure a slight reddening (ear) was observed, which was reversible within 8 days.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met