Registration Dossier
Registration Dossier
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EC number: 907-131-0 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standards.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,6,9-trioxaundecane-1,11-diol
- EC Number:
- 203-989-9
- EC Name:
- 3,6,9-trioxaundecane-1,11-diol
- Cas Number:
- 112-60-7
- Molecular formula:
- C8H18O5
- IUPAC Name:
- 2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Purity: about 90%
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- Body weight male rabbit: 3.48 kg
Body weight female rabbit: 3.49 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 20 h
- Observation period:
- Readings after 24 hours and 8 days
- Number of animals:
- 2
- Details on study design:
- The test substance was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 20 h under occlusive conditions. The skin was either intact or abraded. After the application time, the skin was washed with water which may have contained a mild detergent. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 1 min, 5 min, 15 min and 20 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Irritant / corrosive response data:
- After 20-hour exposure a slight reddening (ear) was observed, which was reversible within 8 days.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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