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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not stated
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results

Data source

Reference Type:
Contact hypersensitivity to glycerol
Hannuksela, M. and Forstrom, L.
Bibliographic source:
Contact Dermatitis 2:291

Materials and methods

Study type:
other: study of 420 consecutive patients with eczema
Test guideline
no guideline available
Principles of method if other than guideline:
Study was conducted on 420 consecutive patients with eczema to determine whether glycerol was an irritant and/or sensitizer to these patients.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
EC Number:
EC Name:
Cas Number:
Molecular formula:
Details on test material:
No additional information available.


Type of population:
other: patients with eczema
No data.
Route of administration:

Results and discussion

Results of examinations:
No irritation was observed. One patient showed allergy to glycerol. This particular patient is on the staff of the allergy laboratory of the dermatological clinic in Helsinki. In january 1976, she noticed eczema on both hands. According to her own observations, a mixture of glycerol (1 part) and 70% ethanol (9 parts) applied on the hands after washing them with soap and water was the apparent cause of the ecezma. Glycerol tested at 1, 5 and 10% in water and the glycerol-ethanol mixture, as is, gave 3+ reaction at 48 and 72-hour readings. The reactions were considered to be allergic. The patient stopped using the glycerol-ethanol mixture, and the eczema disappeared within a couple of days.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

In a study of 420 patients with eczema, 419 showed no irritation or sensitization. One individual reportedly was sensitized but the study design does not prove that.
Executive summary:

In a study of 420 patients with eczema, 419 showed no irritation or sensitization when tested with a 50% solution in water. One individual reportedly was sensitized but the study design does not prove that.