Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-167-4 | CAS number: 79-01-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline study, some restrictions in reporting, nevertheless acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects on experimental animals of acute, repeated and continuous inhalation exposures to dichloroacetylene mixtures.
- Author:
- Siegel J, Jones RA, Coon RA, Lyon JP.
- Year:
- 1 971
- Bibliographic source:
- Toxicol Appl Pharmacol. 1971 Jan;18(1):168-74.
Materials and methods
- Principles of method if other than guideline:
- Determination of the LC50
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Trichloroethylene
- EC Number:
- 201-167-4
- EC Name:
- Trichloroethylene
- Cas Number:
- 79-01-6
- Molecular formula:
- C2HCl3
- IUPAC Name:
- 1,1,2-trichloroethene
- Reference substance name:
- trichloroethene
- IUPAC Name:
- trichloroethene
- Details on test material:
- The substance was obtained commercially. No other details were reported.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: NMRI:O(SD) Sprague-Dawley derived
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No details were reported.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Vapor of TCE was obtained in high concentrations by passing air through a large fritted gas absorber containing the material and then collected in a metallized plastic bag. All exposures were conducted under a fume hood. The animals were exposed for 4 hours and then returned to their individual cages for a 2-week observation period. No food or water was provided during the exposure.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gas chromatography equipped with a hydrogen flame ionisation detector. The chromatograph was equipped with an automatic valve which permitted sampling every 5 min during the exposure periods.
- Duration of exposure:
- 4 h
- Concentrations:
- 6750, 8000 and 14700 ppm.
- No. of animals per sex per dose:
- 16
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: no data - Statistics:
- Not reported.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 12 500 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: Estimated by the method of Miller and Tainter (1944)
- Mortality:
- Mortality rate:
6750 ppm: 2/16
8000 ppm: 3/16
14700 ppm: 10/16
All deaths occurred during exposure. - Clinical signs:
- other: Not reported.
- Body weight:
- Not reported.
- Gross pathology:
- Not reported.
- Other findings:
- Not reported.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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