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EC number: 203-940-1 | CAS number: 112-15-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Urinary excretion of ethoxyacetic acid afterexperimental human exposure to ethylene glycolmonoethyl ether
- Author:
- D GROESENEKEN, H VEULEMANS, R MASSCHELEIN.
- Year:
- 1 986
- Bibliographic source:
- British Journal of Industrial Medicine ;43:615-619.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Not available
- Principles of method if other than guideline:
- Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycolmonoethyl ether.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethanol
- EC Number:
- 203-919-7
- EC Name:
- 2-(2-ethoxyethoxy)ethanol
- Cas Number:
- 111-90-0
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-(2-ethoxyethoxy)ethanol
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report):Diethylene Glycol Ethyl Ether
- Molecular formula (if other than submission substance):CH3CH2–O–CH2CH2–O–CH2CH2–OH
- Molecular weight (if other than submission substance):134.2 g/mol
- Substance type:Organic
- Physical state:Liquid
- Impurities (identity and concentrations):NA
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: Air
- Details on exposure:
- 10 healthy male subjects (aged 19-28)who were exposed for four hours to various concentrationsof EGEE in inspired air, both at rest andduring physical exercise.
- Duration and frequency of treatment / exposure:
- 4 hrs
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Group 1 (at rest): 10mg/m3, 20mg/m3, and 40mg/m3
Group 2 (at rest):20mg/m3
(during physical exercice):30W (20mg/m3) and 60 W (20mg/m3).
- No. of animals per sex per dose / concentration:
- 10 healthy male
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Not available
- Type:
- distribution
- Results:
- Not available
- Type:
- metabolism
- Results:
- Not available
- Type:
- excretion
- Results:
- During exposure, a noticable increase in the rate of excretion of ethoxyacetic acid was observed from first hour of the experiment. The rate continued to increase when exposure was interrupted and reached a maximal level 3 to 4 hrs after end of exposure
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not Applicable,since the use is not as a drug but use in cosmetics and skin care products.
- Details on distribution in tissues:
- Not Applicable
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Ethoxyacetic acid was the main metabolite obtained after urinary excretion.
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- Not available
Any other information on results incl. tables
Before exposure to EGEE, ethoxyacetic acid waseither not present in the urine or present only atconcentrations near the detection limit (approx 0.07 mg/l).During exposure, both at rest and during physicalexercise, a noticable increase in the rate of excretionof ethoxyacetic acid was observed from the first hourof the experiment. The rate continued toincrease when the exposure was interrupted andreached a maximal level three to four hours after theend of the exposure period. Thereafter a slowexponential decrease was observed with a biologicalhalf life between 21 and 24 hours. Even after 42hours, the excretion rate had not returned to baselinevalues.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
The urinary excretion study of the test substance EGEE showed that ethoxyaceticacid was excreted in the urine. On average, 23% of inhaled EGEE was recoveredas ethoxyacetic acid within 42 hours,showing low bioaccumulation potential. - Executive summary:
As soon as exposure to EGEE was started, ethoxyaceticacid was excreted in the urine. These resultssuggest that the metabolism of EGEE in man proceedsprimarily by oxidation and are consistent withthe biotransformation pathways reported for ethyleneglycol monoalkyl ethers in animals. After an initial rise during exposure, the rate of excretionof ethoxyacetic acid continued to increase afterthe exposure was interrupted and maximal levels werereached three to four hours after the end of the fourhour exposure period. Afterwards, the excretion ratedeclined slowly with a biological half life of 21-24 hrs. On average, 23% of inhaled EGEE was recovered as ethoxyacetic acid within 42 hours. No difference was found between experiments at rest and during physical work.
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