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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 3.1: Prediction for LC50 read across evaluation for 112-15-2
Author:
Sustainability Support Services (Europe) AB
Year:
2013
Bibliographic source:
QSAR toolbox Version 3.1

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 3.1
GLP compliance:
no
Test type:
other: Acute Rodent Inhalation Toxicity Test

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-ethoxyethoxy)ethyl acetate
EC Number:
203-940-1
EC Name:
2-(2-ethoxyethoxy)ethyl acetate
Cas Number:
112-15-2
Molecular formula:
C8H16O4
IUPAC Name:
2-(2-ethoxyethoxy)ethyl acetate
Details on test material:
- Name of test material: 2-(2-ethoxyethoxy)ethyl acetate
- Substance type: Organic
- Physical state: Liquid
- SMILES:C(C)(=O)OCCOCCOCC

Test animals

Species:
mouse
Strain:
other: Webster
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
not reported
No. of animals per sex per dose:
5-6 mice per group
Control animals:
yes

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
568.963 mg/L air
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Takes average value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

((("a" and "b" )  and ("c" and ( not "d") )  )  and ("e" and "f" )  )

Domain logical expression index: "a"

Similarity boundary:Target: C(C)(=O)OCCOCCOCC
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as High (Class III) by Toxic hazard classification by Cramer (original)

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 16 - Oxygen O by Chemical elements

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Group 15 - Nitrogen N by Chemical elements

Domain logical expression index: "e"

Parametric boundary:The target chemical should have a value of log Kow which is >= -0.856

Domain logical expression index: "f"

Parametric boundary:The target chemical should have a value of log Kow which is <= 1.62

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Inhalation toxicity (LC50 value) of 2-(2-ethoxyethoxy)ethyl acetate vapours was examined for 4 hrs.in male Webster mouse at a dose concentration of 568.9634 mg/L.
Executive summary:

Inhalation toxicity (LC50 value) of 2-(2-ethoxyethoxy)ethyl acetate vapours was examined for 4 hrs.in male Webster mouse at a dose concentration of 568.9634 mg/L. This value suggests that the chemical 2-(2-ethoxyethoxy)ethyl acetate is non toxic to mouse by the inhalation route.