Registration Dossier
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EC number: 214-946-9 | CAS number: 1222-05-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The key value selected is the BCF in fish of 1584 L/kg ww.
Key value for chemical safety assessment
- BCF (aquatic species):
- 1 584 L/kg ww
Additional information
The available results were reviewed in the EU Risk Assessment Report for HHCB (2008). It was concluded that the key study was the one reported in Balk and Ford (1999), performed by Van Dijk (1996), resulting in BCF = 1584. The BCF from this laboratory study is higher than the BCFs obtained in other laboratory studies. The results obtained from field studies show a lower bioaccumulation. Thus the BCF of 1584 is a conservative value for the risk assessment.
Table from the EU Risk Assessment report HHCB, 2008.
Table 13. Comparison of field derived ratios of Cfish and Cwater to experimentally determined bioconcentration factors for fish
BCF | Chemical analysis | Source |
Bluegill sunfish (28+28)d-BCFwwt = 1584 * | 14C, LC/HPLC | Balk and Ford 1999a |
Zebrafish (14+26)d-BCFwwt = 624 | GC/MS | Butte and Ewald 1999 |
Zebrafish (4d exp)-BCFwwt = 600 a; 2400-2500 b | GC/MS | Schreurs et al 2004 |
Environmental samples: Eel BCFwwt = 150 to 600 non-eel BCFwwt = 49 to 188 | GC/MS/MS | Balk and Ford 1999a from data in Eschke et al. 1995, Rijs and Schäfer 1998, Rimkus 1997 |
Environmental samples: Eel BCFwwt = 862 (range 201 – 1561) | GC/MS | Fromme et al. 2001b |
Eel BCFwwt = 995 | Heberer 2002 from data of Fromme et al. 2001b | |
Environmental samples c : Rudd BCFwwt = 20 Tench BCF wwt = 510 Crucian carp BCF wwt = 580 Eel BCF wwt = 290 Zebra mussel BCF wwt = 620 | GC/MS | Gatermann et al. 2002a |
a Based on initial concentrations
b Based on estimated average concentrations (rel. 3)
c Species differences related to fat content
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