Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

The terrestrial BCF for earthworms for HHCB is calculated with EUSES and results in a BCF of 2400 l/kg, which is considered conservative because it does not consider metabolisation of HHCB.

Key value for chemical safety assessment

BCF (terrestrial species):
2 400 L/kg ww

Additional information

Air-breathing organisms accumulation: Though the bioaccumulation criteria in air breathing organisms are fulfilled for HHCB: Koa > 5 and Kow > 2, the criteria for absence of metabolisation and main excretion pathway via lungs are not fulfilled. Also the indicative final DT50 criteria are not fulfilled. After oral dosing of 2 and 20 mg/kg bw de half-lives in plasma and milk are < 24 hours  In adipose tissue this DT50 is ca 50 hours. This latter DT50 can be compared to the indicative cut off mentioned in ECHA’s PBT guidance (R.11, page 84) of 2.5 days for shrews (a mouse species) and shows that there is no concern for air-breathing organisms (see also toxic-kinetic section).