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EC number: 214-946-9 | CAS number: 1222-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 7 JUNE 1977 to 12 AUGUST 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and OECD guidelines but was conducted according to acceptable procedures at the time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Shorter observation time than recommended in OECD guideline 401: 7 days vs. 14 days
- GLP compliance:
- not specified
- Remarks:
- This study was prior to GLP and OECD guidelines but was conducted according to acceptable procedures at the time.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Galaxolide 50
- Date received: 7/15/77
- Physical state: A clear liquid
- Lot/batch No.: SG-087-2030
- Purity: Assumed 50% active
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 104-141 grams
- Fasting period before study: YES, overnight
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.215, 0.464, 1.0, 2.15 and 4.64 g/kg bw Galaxolide 50, equivalent to doses of HHCB of 0.14, 0.30, 0.65, 1.4 and 3.0 g/kg when corrected for the 65% dilution).
- No. of animals per sex per dose:
- 5 females per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Immediately after dosing at one, four and 24 hrs and once daily thereafter for a total of 7 days.
- Necropsy of survivors performed: yes - Statistics:
- Mortality data was analyzed statistically, utilizing the tables of Horn, HJ. Biometrics 12, 311, 1956.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 4 640 mg/kg bw
- Remarks on result:
- other: The LD50 was >3 g/kg BW expressed in HHCB equivalents.
- Mortality:
- There was one death as a result of gavage error at 1.0 g/kg but no deaths at any other dose
- Clinical signs:
- One animal at 2.15 g/kg appeared distressed shortly after dosing but appeared normal after 2h. There were no effects at the high dose.
Any other information on results incl. tables
Table 1: mortaility in the study.
Time of death | Time of death | |||
Dose (g/kg) | Concentration (%) | Immediate | Hours (1-24) | Days (2-7) |
0.215 | 100 | 0/5 | 0/5 | 0/5 |
0.464 | 100 | 0/5 | 0/5 | 0/5 |
1 | 100 | 0/5 | 1/5 | 1/5 |
2.15 | 100 | 0/5 | 0/5 | 0/5 |
4.64 | 100 | 0/5 | 0/5 | 0/5 |
LD50= >4.64 g/kg total product
Since 50% active LD50= >2.15 g/kg
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The material does not need to be classified for acute oral toxicity.
- Executive summary:
Galaxolide 50 (Non-GLP; 65% HHCB in diethyl phthalate (DEP)) was administered undiluted (hence, there was variation in volume of dosing) by oral intubation at doses of 0.215, 0.464, 1.0, 2.15 or 4.64 g/kg bw (equivalent to doses of HHCB of 0.14, 0.30, 0.65, 1.4, 3.0 g/kg when corrected for the 65% dilution) to groups of 5 female Charles River Sprague Dawley rats (initial bodyweight 104–141 grams) that were then observed for mortality and signs of effects for 7 days. There was one death as a result of gavage error at 1.0 g/kg but no deaths at any other dose. One animal at 2.15 g/kg appeared distressed shortly after dosing but appeared normal after 2 hr. There were no effects at the high dose. An LD50of >4.64 g/kg bw (equivalent to >3 g/kg bw HHCB) was calculated. This study was conducted prior to GLP and OECD guidelines but was conducted according to acceptable procedures at the time.
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