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EC number: 214-946-9 | CAS number: 1222-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 7 JUNE 1977 to 12 AUG 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was carried out prior to GLP and OECD guidelines but was conducted according to acceptable procedure at that time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Animals used where lighter than described in OECD guideline 402. 108 - 187 grams vs 200 - 300 grams
- GLP compliance:
- not specified
- Remarks:
- This study was carried out prior to GLP and OECD guidelines but was conducted according to acceptable procedures at that time.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Galaxolide 50
- Date received: 7/15/77
- Physical state: A clear liquid
- The material as tested was a commercial sample containing 65% HHCB in diethyl phthalate (DEP). The actual LD50 value for HHCB is therefore equivalent to > 6500 mg/kg bw.
- Lot/batch No.: SG-087-2030
- Purity: Assumed 50% active
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals and environmental conditions:
- Initial bodyweight 108-187 g
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 7 days
- Doses:
- 0.464, 1.0, 2.15, 4.64 and 10.0 g/kg bw Galaxolide 50, equivalent to doses of HHCB of 0.30, 0.65, 1.4, 3.0 and 6.5 g/kg when corrected for the 65% dilution
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Immediately after dosing at one, four and 24 hrs and once daily thereafter for a total of 7 days.
- Necropsy of survivors performed: yes - Statistics:
- Mortality data was analyzed statistically, utilizing the tables of Horn, HJ. Biometrics 12, 311, 1956.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Remarks on result:
- other: The LD50 was > 6500 mg/kg BW expressed in HHCB equivalents.
- Mortality:
- There were no deaths at any dose.
- Clinical signs:
- All animals in the high dose group exhibited urine staining on their fur.
- Gross pathology:
- There were no major effects noted in any of the animals in any dosage level.
Any other information on results incl. tables
Time of death | Time of death | Time of death | ||
Dose (g/kg) | Concentrations (%) | Immediate | Hours (1 -24) | Days (2 -7) |
0.464 | 100 | 0/5 | 0/5 | 0/5 |
1 | 100 | 0/5 | 0/5 | 0/5 |
2.15 | 100 | 0/5 | 0/5 | 0/5 |
4.64 | 100 | 0/5 | 0/5 | 0/5 |
10 | 100 | 0/5 | 0/5 | 0/5 |
LD50= > 10 g/kg total product
Since 50% active, LD50 = > 5 g/kg
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The material does not need to be classified for acute dermal toxicity
- Executive summary:
Galaxolide 50 (65% HHCB in DEP) was administered undiluted by inunction to the shaved skin (area not reported) of groups of five female Charles River Sprague Dawley rats (initial bodyweight 108–187 g) in doses of 0.464, 1.0, 2.15, 4.64 or 10.0 g/kg bw (equivalent to 0.30, 0.65, 1.4, 3.0, 6.5 g/kg HHCB) that were then observed for 7 days. There were no deaths at any dose but all animals in the high dose group exhibited urine staining on their fur. A dermal LD50 of >10.0 g/kg bw (equivalent to >6.5 g/kg bw HHCB) was reported (Minner and Foster, 1977). This study was conducted prior to GLP and OECD guidelines but was conducted according to acceptable procedures at the time.
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