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Administrative data

Description of key information

Not irritating to the skin.

Not irritating to the eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The skin irritation potential of the test substance was determined according to OECD 404 (Shell, 1987). The test substance was applied to the intact skin of rabbits for 4 hours under semiocclusive conditions. After removal of the test substance, no edema, but minimal erythema were noted in all animals (score 1). At 72 hours, all rabbits were still affected. All skin effects had cleared by 7 days.


In another study, the test substance was placed on intact skin of 4 rabbits, and covered with an occlusive patch (Shell, 1977). After 24 hours of exposure, animals were scored for dermal irritation (24, 48 and 72 h and 7 days after patch removal). Very slight erythema (score 1) were observed in all animals. Very slight edema were only observed at 24 hours after removal of the patches. Based on the experimental data, the test substance was not irritating to the skin.


The eye irritation potential of the hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was determined by instillation of 0.2 mL of the test material into the conjunctival sac of 4 rabbits (Shell, 1977). A visual assessment of irritancy was made 30 min, 24, 48, 72 hours and 7 days after application. At 30 min after application, a very mild irritancy was observed in mild conjunctival redness (grade 0-1) in all animals. All redness was reversible within 24 hours. No corneal opacity, iritis, conjunctival chemosis, or discharge was noted in any of the 4 rabbits.

Justification for classification or non-classification

Based on the available data, Hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics do not warrant classification as skin irritants and do not warrant classification as eye irritants.