Registration Dossier
Registration Dossier
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EC number: 223-861-6 | CAS number: 4098-71-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Cited from SIAR for SIAM 23 (Jeju, Korea, October 17-20, 2006):
"The only information available on the toxicokinetics of 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate results from a test chamber exposure of three volunteers to concentrations of 0.0121, 0.0177 and 0.0507 mg /m3 for 2 hours at day 1, 3, and 5, respectively. After hydrolysis of blood and urine samples the corresponding amine, 3-aminomethyl-3,5,5-trimethylcyclohexylamine, was detected in urine but not in plasma. The average urinary excretion was 27% and urinary elimination half-time was 2.8 hours. No 3-aminomethyl-3,5,5-trimethylcyclohexylamine was observed in samples without hydrolysis from exposed persons."
Key value for chemical safety assessment
Additional information
Partly cited from SIAR for SIAM 23 (Jeju, Korea, October 17-20, 2006):
Studies in Animals
"There are no data available on the metabolic fate of 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate in experimental animals."
Studies in Humans
"Three healthy male volunteers were exposed in a 5.6 m3 exposure chamber to 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate concentrations of 0.0121, 0.0177, and 0.0507 mg/m3 for 2 hours at day 1, 3, and 5, respectively. All urine was collected for 16 days, and blood samples were taken before and half an hour after exposure, and daily on exposure-free days. After hydrolysis 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate was determined as 3-aminomethyl-3,5,5-trimethylcyclohexylamine.When working up samples from exposed persons without hydrolysis, no 3-aminomethyl-3,5,5-trimethylcyclohexylamine was seen. This indicates that the test substance was available in the urine only as conjugate. Hydrolysis had to split the conjugates and convert any residual isocyanate functions that might have been stabilized by conjugation, to amine functions. The average urinary elimination half-time was 2.8 hours. The average urinary excretion of the corresponding amine was 27% (range 19 -46%). An association between the estimated inhaled dose and the total excreted amount was seen. No 3-aminomethyl-3,5,5-trimethylcyclohexylamine was found in hydrolyzed plasma (Tinnerberg et al., 1995)."
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