Registration Dossier
Registration Dossier
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EC number: 245-018-1 | CAS number: 22464-99-9
Endpoint summary
Administrative data
Description of key information
Additional information
Read-across approach
In the assessment of the environmental fate, ecotoxicity and toxicity of 2-ethylhexanoic acid, zirconium salt (CAS: 22464-99-9), a read-across approach from data for the metal (zirconium) and the organic anion (2-ethylhexanoate) is followed. This read-across strategy is based upon the observation that upon dissolution in aqueous media, 2-ethylhexanoic acid, zirconium salt completely dissociates and only is present in its dissociated form, i.e., as zirconium and 2-ethylhexanoate ions. Data on the environmental fate, ecotoxicity and toxicity for both transformation products (zirconium and 2-ethylhexanoate) together can therefore be combined in an additive approach to predict the corresponding properties of 2-ethylhexanoic acid, zirconium salt.
A detailed justification for the read-across approach is added as a separate document in section 13 of IUCLID.
Upon dissolution and dissociation of 2-ethylhexanoic acid, zirconium salt into zirconium and 2-ethylhexanoate, both ions will each show the proper (bio)degradation, bioaccumulation and partitioning behaviour in the environment, as reported for the corresponding ion. The environmental fate and behaviour for zirconium and 2-ethylhexanoate is predicted to be clearly different from each other, resulting in a different relative distribution over the environmental compartments (water, air, sediment and soil). Because the relative exposure to both constituent ions is hence predicted to be different from the original composition of 2-ethylhexanoic acid, zirconium salt, data for the ecotoxicological properties of this substance tested as such are considered less relevant for its effects and risk assessment and a read-across approach from data for both the zirconium and 2-ethylhexanoate ions is preferred. The dose additivity approach is used to explain the ecotoxicological effects of 2-ethylhexanoic acid, zirconium salt based on the data for the individual transformation products (zirconium and 2-ethylhexanoate ions).
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