2,2'-methyliminodiethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1996

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Acute toxicity study in which Sprague-Dawley albino rats were exposed in groups of 5 to saturated vapor atmospheres for 6 h.

GLP compliance:

not specified

Test type:

other: Inhalation Risk Test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-methyliminodiethanol

EC Number:

203-312-7

EC Name:

2,2'-methyliminodiethanol

Cas Number:

105-59-9

Molecular formula:

C5H13NO2

IUPAC Name:

2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

Sprague-Dawley albino rats were exposed in groups of 5 to saturated vapour atmospheres for 6 h. The static generation procedure involved placing approximately 50 g of test material into a 120 L exposure chamber and sealing for approximately 18 h. Animals were then introduced into the exposure chamber by means of a gasketted drawer which limited leakage of vapor. The dynamic conditions involved passing filtered compressed air through the test material contained in a gas washing bottle and transferring the vapor atmosphere to a 120 L chamber containing the rats.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

6 h

Concentrations:

saturated vapor

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: during exposure, immediately following exposure, and thereafter daily for 2 weeks
- Frequency of weighing: before exposure and at 7 and 14 d post-exposure
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

other: Inhalation Risk Test

Exp. duration:

6 h

Remarks on result:

other: a saturated vapour of MDEA caused no mortality

Mortality:

no mortality occured

Clinical signs:

other: no significant signs of toxicity observed

Body weight:

no data

Gross pathology:

no data

Any other information on results incl. tables

No mortality was observed when 5 rats were exposed for 6 hours to an atmosphere that has been saturated at room temperature with the volatile part of the compound.