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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

No data are available for sodium tert-butanolate. But a study with potassium tert-butanolate was performed according to OECD guideline 401 (Evonik, 1989). 5 rats received 510, 631, or 794 mg/kg bw of Potassium tert-butanolate by oral gavage. At 631 mg/kg 4/10 rats died, at an applied dose of 794 7/10 animals died. The calculated LD50 was 690 mg/kg bw for male and female.

No data are available for dermal and inhalative acute toxicity and testing is not meaningful due to its corrosive properties.

Justification for classification or non-classification

Based on the available acute oral toxicity data for Potassium tert-butanolate, criteria for classification are fulfilled for acute toxicity with R22 (harmful if swallowed), according to 67/548/EEC and acute tox. Cat 4, H302 according to 1272/2008/EC (CLP, GHS).

But for classification purposes, it has to be considered that sodium tert-butanolate is classified as skin corrosive Cat 1B (H314) or C: R34. The acute oral toxicity is based on corrosive properties of the test substance, therefore no classification is proposed.