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EC number: 236-813-4 | CAS number: 13494-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-01-31 to 1996-02-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tellurium
- EC Number:
- 236-813-4
- EC Name:
- Tellurium
- Cas Number:
- 13494-80-9
- Molecular formula:
- Te
- IUPAC Name:
- hydrogen telluride
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Tellurium
- Substance type: inorganic
- Physical state: fine grey powder
- Analytical purity: > 99.5 %
- Lot/batch No.: GI1631/95
- Storage condition of test material: ambient
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga, Sulzfeld, Germany
- Age at study initiation: 5 - 6 weeks old upon arrival
- Weight at study initiation:
- Fasting period before study: overneight
- Housing: five animals per cage (stainless steel cages, fitted with wire screen floor and front)
- Diet (e.g. ad libitum): standard laboratory rat diet ad libitum
- Water (e.g. ad libitum): Tap water ad libitum.
- Acclimation period: 21 - 23 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): between 32. 5 - 80 %
- Air changes (per hr): ca 10 air changes/hour
- Photoperiod (hrs dark / hrs light): 12 hours Iight/12 hours dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 % w/v
MAXIMUM DOSE VOLUME APPLIED: 10 mL/ kg max. Dose volume - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/ sex/ dose
- Control animals:
- no
- Details on study design:
- A screening was carried out with two females treated with a dose level of 5000 mg/kg body weight to check for mortality. Since no mortality was observed, the study was continued with three females and five males which were treated with the same dose level. All animals were dosed with a 500 mg/mL suspension in maize oil and a 10mL/kg body weight dosing volume.
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were made within 1 hour and within 4 hours after dosing, and subsequently at least once daily throughout the observation period of 14 days; body weights were recorded on day 0, 3, 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during the 14-day observation period.
- Clinical signs:
- other: No clinical symptoms were observed.
- Gross pathology:
- Examination of the animals at autopsy did not reveal any treatment-related gross alterations.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU GHS (Regulation (EC) No 1272/2008)
- Conclusions:
- The LD50 for tellurium (powder) was determined to be above 5000mg/kg bw .
- Executive summary:
This acute oral toxicity study was conducted according to OECD Guideline 401 (Acute Oral Toxicity). A screening was carried out with two female Wistar rats treated with a dose level of 5000 mg/kg bw to check for mortality. Since no mortality was observed, the study was continued with three females and five males which were treated with the same dose level and observed for 14 days.
No clinical symptoms were observed and no mortality occurred during the 14-day observation period. All animals gained weight during the 14-day observation period.
Examination of the animals at autopsy did not reveal any treatment-related gross alterations.
Since no mortality occurred during the 14-day observation period, the oral LD50of tellurium is considered to exceed 5000 mg/kg bw in both male and female rats.
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