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EC number: 236-813-4 | CAS number: 13494-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-01-22 to 1991-02-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tellurium
- EC Number:
- 236-813-4
- EC Name:
- Tellurium
- Cas Number:
- 13494-80-9
- Molecular formula:
- Te
- IUPAC Name:
- hydrogen telluride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Tellurium
- Substance type: inorganic
- Physical state: fine black powder
- Analytical purity: > 99.5 %
- Lot/batch No.: 1103
- Storage condition of test material: first at 4 °C in the dark, later at ca. 20 °C
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan/CPB, Austerlitz, the Netherlands
- Age at study initiation: 5-6 weeks old
- Weight at study initiation:
- Fasting period before study: 4 hours before dosing
- Housing: five females per cage, macrolon, type II, males individually in macrolon casegs type I.
- Diet (e.g. ad libitum): standard laboratory mice diet ad libitum
- Water (e.g. ad libitum): Tap water ad libitum.
- Acclimation period: 7 - 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): between 52 - 62 %
- Air changes (per hr): ca 10 air changes/hour
- Photoperiod (hrs dark / hrs light): 12 hours Iight/12 hours dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 % w/v
MAXIMUM DOSE VOLUME APPLIED: 10 mL/ kg max. Dose volume - Doses:
- Preliminary study: 250, 500, 1000, 2000 and 5000 mg/kg bw
Main study: 5000 mg/kg bw - No. of animals per sex per dose:
- Preliminary study: 2 females/ dose
Main study: 5 animals/ sex/ dose - Control animals:
- no
- Details on study design:
- A preliminary test to determine the approximate level of acute oral toxicity was carried out with five groups of 2 females each. The five dose levels were 250, 500, 1000, 2000 and 5000 mg/kg bw. The dilutions prepared in the preliminary test were 25, 50, 100, 200 and 500 mg tellurium per mL maize oil and the dosing- volume was 10 mL/kg body weight.
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were made within 1 hour and within 4 hours after dosing, and subsequently at least once
daily throughout the observation period of 14 days; body weights were recorded on day 0, 3, 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
- Preliminary study:
- In the preliminary experiment, no mortality occurred during the 7-day observation period nor did the animals show any signs of abnormal behavior or abnormal appearance that could be ascribed to treatment with the test substance. On the basis of these results, it was decided to perform the main study with a limit-dose of 500 mg/kg body weight.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during the 14-day observation period.
- Clinical signs:
- The animals did not show any signs of abnormal behavior or abnormal appearance that could be ascribed to treatment with the test substance.
- Body weight:
- All animals gained weight during the 14-day observation period.
- Gross pathology:
- Examination of the animals at autopsy did not reveal any treatment-related gross changes.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU GHS (Regulation (EC) No 1272/2008)
- Conclusions:
- The LD50 for tellurium (powder) was determined to be above 5000mg/kg bw .
- Executive summary:
This acute oral toxicity study was conducted according to OECD Guideline 401 (Acute Oral Toxicity). A preliminary test to determine the approximate level of acute oral toxicity was carried out at dose levels of 250, 500, 1000, 2000 and 5000 mg/kg bw with 2 females each. No mortality and no treatment related effects were observed.
In the main study Swiss mice were given a single oral dose of tellurium (powder) in maize oil at a dose of 5000, mg/kg bw (5 animals/sex/ group) and observed for 14 days.
No mortality occurred. The animals did not show any signs of abnormal behavior or abnormal appearance that could be ascribed to treatment with the test substance.
All animals gained weight during the 14-day observation period.
Examination of the animals at autopsy did not reveal any treatment-related gross alterations.
Since no mortality occurred during the 14-day observation period, the oral LD50of tellurium is considered to exceed 5000 mg/kg bw in both male and female mice.
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