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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: EC Methods for Determination of Ecotoxicity, Annex to Directive 92/69/EEC (O.J. No. L383A, 1992) Part C, Method 2 Acute Toxicity For Daphnia OECD Guideline for Testing of Chemicals No. 202, Daphnia sp., Acute Immobilisation Test (2004).
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test solutions

Details on test solutions:
Identity and concentration of auxiliary solvent for dispersal: The test substance (500 mg) was dissolved in dimethylformamide (10 ml) to give a concentrated stock solution with a nominal concentration of 50 mg/ml. This solution was serially diluted to give intermediate solvent stocks with nominal concentrations of 2.13, 4.67, 10.3 and 22.7 mg/ml.

Test organisms

Test organisms (species):
other aquatic crustacea: DM

Study design

Test type:
static
Water media type:
freshwater

Test conditions

Hardness:
268 mg CaCO3/L

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
>= 2.05 mg/L
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
1.82 mg/L
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
2.72 mg/L
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
1.41 mg/L

Applicant's summary and conclusion

Conclusions:
The 48-hour EC50 of Trimofix O for the immobilisation of Daphnia magna was 1.82 mg/l (95% confidence limits of 1.41 and 2.01 mg/l).
The ‘no-observed effect concentration’ of Trimofix O with Daphnia magna was 1.41 mg/l.
Executive summary:

The 48-hour EC50 of Trimofix O for the immobilisation of Daphnia magna was 1.82 mg/l (95% confidence limits of 1.41 and 2.01 mg/l). The ‘no-observed effect concentration’ of Trimofix O with Daphnia magna was 1.41 mg/l.