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Short-term toxicity to aquatic invertebrates

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Description of key information

The estimated 96 hour LC50 for aquatic invertebrates was calculated to range from 14.22 to 69.43 mg/L

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
14.22 mg/L

Additional information

No experimental data were available on the short-term toxic effects of category members on aquatic invertebrates. Due to the difficulty associated with aquatic toxicity testing with gases, QSAR calculations are considered suitable to estimate the effect concentration. ECOSAR Program v1.00 in EPI Suite v4.00 was used, which is acceptable with restrictions. The ECOSAR model is a reliable and appropriate QSAR model to apply to these substances as it is based on a related chemical dataset that calculates the toxicity of neutral organic hydrocarbons whose mode of action is non-polar narcosis.

QSAR calculations were conducted for substances which were representative of the carbon numbers of the members of the category (methane, ethane, propane, butane and isobutane). The 48 hour LC50 for invertebrates is estimated to range from 14.22 to 69.43 mg/L in fresh water.