Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-712-3 | CAS number: 69-72-7
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- other: Critical analysis
- Adequacy of study:
- key study
- Study period:
- 2012
- Rationale for reliability incl. deficiencies:
- other: Critical analysis of 80 epidemiological data.
Data source
Referenceopen allclose all
- Reference Type:
- other: Report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
- Reference Type:
- other: Report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
- Study type:
- cohort study (retrospective)
- Endpoint addressed:
- toxicity to reproduction / fertility
- developmental toxicity / teratogenicity
- GLP compliance:
- not specified
Test material
- Reference substance name:
- O-acetylsalicylic acid
- EC Number:
- 200-064-1
- EC Name:
- O-acetylsalicylic acid
- Cas Number:
- 50-78-2
- Molecular formula:
- C9H8O4
- IUPAC Name:
- 2-acetoxybenzoic acid
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- There is no link between ASA use during pregnacy and reprotoxic effects. Epidemiologiocal data do not provide evidence to support the hypothesis that maternal consumption during pregnancy of NSAIDs overall (including ASA) is associated with persistent pulmonary hypertension of the newborn risk.
- Executive summary:
As a final conclusion, no adverse effect of aspirin treatment can be considered as established, either at low or high dose.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
