4,4'-oxydi(benzenesulphonohydrazide)

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1994

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 305 E (Bioaccumulation: Flow-through Fish Test)

Deviations:

not applicable

Principles of method if other than guideline:

NA

GLP compliance:

yes

Radiolabelling:

no

Test organisms (species):

Cyprinus sp.

Details on test organisms:

Cyprinus sp. (fish, fresh water)

Route of exposure:

aqueous

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

<= 42 d

Test temperature:

25 degrees celcius

Details on test conditions:

42 day(s) at 25 °C
A number of fish were exposed to 0.1 and 1 mg/l of the test substance solutions for 6 weeks

Reference substance (positive control):

not specified

Details on estimation of bioconcentration:

All measured values were lower than the detection limit, so a BCF could not be determined experimentally. Therefore, BCF values were calculated based on the limit of the detection of HPLC, 0.3 and 3 for 0.1 mg/l and 1mg/l of test concentrations, respectively.

BCF = 3.162

Type:

BCF

Value:

0.3 dimensionless

Remarks on result:

other: Conc.in environment / dose:0.1 mg/L

Type:

BCF

Value:

3 dimensionless

Remarks on result:

other: Conc.in environment / dose:1 mg/L

Details on kinetic parameters:

no data

Metabolites:

no data

Results with reference substance (positive control):

no data

Details on results:

All measured values were below the detection limit. Therefore, BCF values were calculated based on the limit of the detection of HPLC, 0.3 and 3 for 0.1 mg/l and 1mg/l of test concentrations, respectively

Validity criteria fulfilled:

not specified

Conclusions:

All measured values were lower than the detection limit. BCF values were, therefore, calculated based on the limit of the detection of HPLC, 0.3 and 3 for 0.1 mg/l and 1mg/l of test concentrations, respectively.

Executive summary:

A number of fish were exposed to 0.1 and 1 mg/l of the test substance solutions for 6 weeks.

All concentrations were below the detection limit. Therefore, BCF values were calculated based on the limit of the detection of HPLC; 0.3 and 3 for 0.1 mg/l and 1mg/l of test concentrations, respectively.

In conclusion, the test substance is not bioaccumulative in fish.

Description of key information

In a reliable study according to OECD 305, BCF values were calculated based on the limit of the detection of HPLC; for 0.1 mg/L test concentration a BCF of 0.3 and for 1 mg/L a BCF of 3 were calculated, respectively.

In a supporting study, a calculated BCD of 3.2 was derives by EpiSuite (BCFWIN v 2.15).

Key value for chemical safety assessment

BCF (aquatic species):

3 L/kg ww

Additional information

BCF was calculated by EpiSuite.