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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982-06-23 to 1982-07-20
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP; Scientifically well performed study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-(2-methoxyethoxy)ethyl) ether
EC Number:
205-594-7
EC Name:
Bis(2-(2-methoxyethoxy)ethyl) ether
Cas Number:
143-24-8
Molecular formula:
C10H22O5
IUPAC Name:
2,5,8,11,14-pentaoxapentadecane

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
2500, 3150, 3550, 3750, 4000, 5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes/
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
3 850 mg/kg bw
Based on:
act. ingr.
95% CL:
> 3 640 - < 4 160
Mortality:
Dose (mg/kg bw) number of dead animals/total animals
2500, 0/10
3150, 0/10
3550, 1/10
3750, 5/10
4000, 9/10
5000 , 9/10

animal died on day 2-4 after administration
Clinical signs:
hyperactivity, then passivity, dizziness, deep anesthesia, balance disturbance, ataxia, squatting position, prone position, dorsal position, lateral position, twitching, orthotonus hyporeflexia, negative miosis pupil, muco serous nasal discharge, skin redness, snapping breathable, and noisy breathing
Body weight:
normal in survived animals
Gross pathology:
in dead animals: intestinal tract filled with black pulpy mass and diffuse redness, red diffuse pancreas, adrenal colored red-brown bubble, bladder steeply filled, orange to pink to red lung, skin redness.

Any other information on results incl. tables

no

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The median lethal dose of Tetraethylenglycodimethylether (LD50) was 3850 mg per kg body weight. Based on the result of this study Tetraethylenglycodimethylether is not subject for labelling and classification requirements according to regulatory requirements.
Executive summary:

The acute toxicity was tested using female Wista rats. The animal received a single dose of the test item by gavage and were observed for 14 days.

The median lethal dose of Tetraethylenglycodimethylether (LD50) after single oral administration was 3850 mg per kg body weight. Based on the result of this study Tetraethylenglycodimethylether is not subject for labelling and classification requirements according to regulatory requirements.