Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Skin sensitasation potential was assessed based on analogue approach using ethoxymethoxy diethylene glycol (EMDE) and 2 -methoxyethanol (2-ME) as source chemicals.

 

The underlying scientific rationales are based on the structural similarity and metabolic consideration.

- EMDE is structurally related to the target chemical, exhibiting same chemical functional groups (ethylene glycol chain, methoxy moiety as well as the structural feature to be metabolized to 2-Methoxyethanol and 2-Methoxyacetic acid).

- 2-ME is the metabolite of tetraglyme.

 

Considering that the source chemicals comprises the structurally related substance (EMDE) and the presumed metabolites (2 -ME), it can be assumed that the major events leading to skin sensitization are well covered. Neither EMDE nor 2 -ME exhibited significant sensitization potential. Likewise, tetraglyme is considered to be a non skin sensitizer. 



Migrated from Short description of key information:
The skin sensitization potential of tetraglyme can reliably derived based on the read-across approach and is considered to be low. No classification is warranted.

Justification for selection of skin sensitisation endpoint:
Two studies are proposed to be used as weight of evidence.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

There are no respiratory sensitization properties of the substance known in literature. Beyond this there is no hint of any sensitization property of the source chemicals of EMDE or 2 -ME for the analogue approach. Therefore, it is concluded that the subsance is not a respiratory sensitizer.


Migrated from Short description of key information:
It is concluded that the subsance is not a respiratory sensitizer based on the available informaion.

Justification for classification or non-classification

No classification is warranted for tetraglyme based on the read-across approach and the available information.