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Diss Factsheets
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EC number: 203-733-6 | CAS number: 110-05-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: sewage treatment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well conducted GLP study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 303 A (Simulation Test - Aerobic Sewage Treatment. A: Activated Sludge Units)
- Deviations:
- yes
- Remarks:
- As the test item was shown to be extremely volatile under aeration in the preliminary investigational work, no further work will be conducted for this study as aeration is needed for this study type.
- Principles of method if other than guideline:
- This report contains a description of the methods used and results obtained during preliminary investigational work to investigate the volatility of the test item when exposed to aerobic conditions. The results of the preliminary investigational work are of value in the assessment of the volatility
of the test item in the aquatic environment, and the suitability of the proposed method of
accessing the biodegradation of the test item. - GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: reverse osmosis water
- Remarks:
- preliminary scoping of technical feasibility due to substance volatility
- Details on source and properties of surface water:
- Not applicable
- Details on source and properties of sediment:
- Not applicable
- Details on inoculum:
- Not applicale
- Details on study design:
- Preliminary Investigational Work:
Information provided by the Sponsor indicated that the test item was extremely volatile.
Therefore preliminary investigational work was performed in order to investigate this.
An amount oftest item (100 mg) was dissolved in reverse osmosis water (1 liter) with the aid of
shaking by hand for approximately 1 minute and sonication for 6 minutes to give a 100 mg/L
stock solution. One untreated sample was taken for DOC analysis. This stock solution was then
subjected to aeration (1.0 Llmin) for 24 hours in darkness and a further untreated sample taken
for DOC analysis. A control sample containing reverse osmosis water was prepared to correct
the DOC values.
Due to the light sensitive nature of the test item once formulated the volumetric flask containing
the stock solution was shielded from light with aluminum foil.
The samples were analyzed for DOC using a Shimadzu TOC-VcsH TOC analyzer - Test performance:
- The results obtained from the samples taken for DOC analysis from the preliminary investigational work indicated that the test item was extremely volatile in solution when being subjected to aeration. The failure to achieve a near nominal carbon content prior to aeration indicated significant losses
of test item through volatilization occurred during the initial preparation of the stock solution,
further confirming the unsuitability of the test item for this particular study type. - % Degr.:
- 0
- Parameter:
- not specified
- Sampling time:
- 0 min
- Remarks on result:
- other: substance too volatile for reliable test to be conducted
- Compartment:
- other:
- DT50:
- ca. 0 min
- Type:
- not specified
- Remarks on result:
- other: substance too volatile for reliable test to be conducted
- Transformation products:
- not specified
- Details on results:
- The results obtained from the samples taken for DOC analysis from the preliminary investigational work indicated that the test item was extremely volatile in solution when being subjected to aeration. The failure to achieve a near nominal carbon content prior to aeration indicated significant losses
of test item through volatilization occurred during the initial preparation of the stock solution,
further confirming the unsuitability of the test item for this particular study type. - Results with reference substance:
- Not applicable.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The results obtained from the samples taken for DOC analysis from the preliminary investigational work indicated that the test item was extremely volatile in solution when being subjected to aeration (see Table 1).
The failure to achieve a near nominal carbon content prior to aeration indicated significant losses
of test item through volatilization occurred during the initial preparation of the stock solution,
further confirming the unsuitability of the test item for this particular study type. - Executive summary:
This report contains a description of the methods used and results obtained during preliminary investigational work to investigate the volatility of the test item when exposed to aerobic conditions. The results of the preliminary investigational work are of value in the assessment of the volatility of the test item in the aquatic environment, and the suitability of the proposed method of accessing the biodegradation of the test item.
The results obtained from the samples taken for DOC analysis from the preliminary investigational work indicated that the test item was extremely volatile in solution when being subjected to aeration (see Table 1). The failure to achieve a near nominal carbon content prior to aeration indicated significant losses of test item through volatilization occurred during the initial preparation of the stock solution, further confirming the unsuitability of the test item for this particular study type.
The preliminary investigational work conducted confirmed that the test item was extremely volatile when subject to aeration and under the test conditions that are employed for this study type this study would not be suitable for this test item.
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Endpoint:
- biodegradation in water: sediment simulation testing
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Referenceopen allclose all
The results obtained from the samples taken for DOC analysis from the preliminary investigational work indicated that the test item was extremely volatile in solution when being subjected to aeration. The failure to achieve a near nominal carbon content prior to aeration indicated significant losses of test item through volatilization occurred during the initial preparation of the stock solution, further confirming the unsuitability of the test item for this particular study type.
Description of key information
Preliminary investigational work for an OECD 303A test is available, showing that the test substance is too volatile to be analysed in this test.
Key value for chemical safety assessment
Additional information
The results obtained from the samples taken for DOC analysis from the preliminary investigational work indicated that the test item was extremely volatile in solution when being subjected to aeration. The failure to achieve a near nominal carbon content prior to aeration indicated significant losses of test item through volatilization occurred during the initial preparation of the stock solution, further confirming the unsuitability of the test item for this particular study type.
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