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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Uptake via inhalation is not anticipated for NOM, while dermal absorption is feasible. Significant accumulation in fatty tissue is highly unlikely.
Key value for chemical safety assessment
Additional information
The natural oil monomer consists of esters of the fatty acids palmitic acid (C16), margaric acid (C17) and stearic acid (C18), and C16-C18 fatty acids with one or more methanol side groups on the chain. The methyl groups are likely to hydrolyse readily. Palmitic and stearic acid are endogenous compounds and are present in abundance in our food. Margaric acid is a naturally occurring dietary fat present in our food, but this fatty acid is not synthesized by the human body.
The fatty acids are anticipated to be distributed, metabolized and excreted in the same way as naturally occurring fatty acids. Fatty acids with an additional methanol side group are expected to follow these same pathways, with the additional potential for Phase II conjugation of the methanol moieties of these components. Significant accumulation in fatty tissue is highly unlikely. The anticipated toxicokinetic behaviour of NOM is consistent with the low toxicity of the substance.
Discussion on absorption rate:
Dermal uptake for NOM is possible. Conversely, fatty acids and fatty acid methyl esters are used as penetration enhancers for drug delivery (Chukwumerije et al., 1989; Kogan and Garti, 2006) and thus, it is expected that the fatty acid properties of MPS would allow for dermal penetration. Consistent with the uses for drug delivery, dermal absorption of fatty acids are generally regarded as safe, and the toxicity profile of MPS following dermal testing is consistent with this as well. The dermal absorption of MPS has not been studied to date. However, the permeability of this compound through skin can be estimated with QSAR programs, such as the DermWin model from the US EPA. Using this application, the steady-state flux of a 1% solution of MPS through skin is estimated to be 0.65-240 mg/cm2 surface area of skin, for the various components. The calculated Kp, or rate of penetration via the DermWin model, is calculated to be 1.28-24.4 cm/hr.
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