Registration Dossier
Registration Dossier
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EC number: 233-237-5 | CAS number: 10099-58-8
Endpoint summary
Administrative data
Description of key information
oral: LD50 (rat) = 2621 mg/kg bw Lanthanum chloride, anhydrous (original value: 3200 mg/kg bw Lanthanum chloride trihydrate)
dermal: LD50 (rabbit) > 1638 mg/kg bw Lanthanum chloride, anhydrous ((original value: > 2000 mg/kg bw Lanthanum chloride trihydrate)
Key value for chemical safety assessment
Additional information
Oral
The acute oral toxicity of Lanthanum chloride trihydrate was tested according to the Guideline of the Department of Transportation (D.O.T), Code of Federal Regulations, Title 49, Part 173. The test substance was administered to rats at a dose range of 2820 - 4470 mg/kg bw, mortality and clinical signs were observed for 48 h. The LD50 was 3200 mg Lanthanum chloride trihydrate/kg bw, corresponding to 2621 mg Lanthanum chloride, anhydrous/kg bw.
Inhalation
There are no data available on acute inhalation toxicity of lanthanum chloride.
Dermal
The acute dermal toxicity of Lanthanum chloride trihydrate was tested according to the Guideline of the Department of Transportation (D.O.T), Code of Federal Regulations, Title 49, Part 173. After acute dermal application of 2000 mg/kg bw to the intact skin of rabbits for 24 h under occlusive conditions, no signs of systemic toxicity were observed after an observation time of 48 h. The intact skin showed very slight erythema and very slight edema after 24 h, no signs of erythema and edema were detected after 48 h. The LD50 can be stated as > 2000 mg Lanthanum chloride trihydrate, corresponding to > 1638 mg Lanthanum chloride, anhydrous/kg bw.
Other routes
Localisation and biological effects of an intratracheal instillation of up to and including 50 µg Lanthanum chloride/rat was investigated (Suzuki et al., 1992). Sacrifice of exposed animals at various time points (3 hours to 168 days) after treatment revealed that Lanthanum accumulated in a dose-related manner in the lung in an insoluble form resulting in a biological half-life of approximately 244 days. In addition, administered Lanthanum chloride could not only be detected in various cell types in the lung but also in pulmonary lymph nodes.
Justification for classification or non-classification
There are conclusive data available, but they are not sufficient for classification.
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