Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-237-5 | CAS number: 10099-58-8
Lanthanum chloride is not irritating to the skin, but at the same time causes serious eye damage.
The skin irritation was investigated according to the Guidelines of the Federal Hazardous Substances Act (1973) and Title 49-Transportation Section 173.240 (Calkins 1978). An aqueous paste of Lanthanum chloride, unhydrous was applied to the intact skin under occlusive conditions for 4 h. No signs of erythema and edema were observed during an observation period of 72 h, so Lanthanum trichloride, anhydrous was not irritating to the skin.
The eye irritation was investigated according to OECD 405 under GLP-conditions (Manciaux 2000). 0.1 mL of a Lanthanum chloride solution with a concentration of 24% was instilled in the eyes of rabbits and without removal, the eyes were examined up to 21 days after instillation. Very slight to moderate conjunctival reactions were observed in all animals from day 1: a very slight to moderate chemosis (grade 1 to 3) and a very slight to moderate redness of the conjunctiva (grades 1 to 3). The reactions persisted up to the end of the observation period (day 21). A slight iritis (grade 1) was noted in all animals on day 2, it persisted up to day 5 or 8. A very slight or slight corneal opacity (grades 1 to 2) was recorded in all animals from day 2. It persisted up to the end of the observation period (day 21) in two animals. Mean scores calculated for each animal over 24, 48 and 72 h were: 3.0, 3.0 and 2.0 for chemosis; 3.0, 2.0 and 2.0 for redness of the conjunctiva; 1.0, 1.0 and 1.0 for iris lesions and 1.0, 2.0 and 2.0 for corneal opacity. The effects were not fully reversible during the observation period of 21 days.
Based on the available data, lanthanum trichloride, anhydrous has to be classified:
CLP: Eye damage category 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again