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EC number: 215-572-9 | CAS number: 1332-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with Good laboratory Practice and internationally accepted guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dicopper chloride trihydroxide
- EC Number:
- 215-572-9
- EC Name:
- Dicopper chloride trihydroxide
- Cas Number:
- 1332-65-6
- Molecular formula:
- ClCu2H3O3
- IUPAC Name:
- dicopper chloride trihydroxide
- Details on test material:
- - Name of test material (as cited in study report): Copper oxychloride
- Composition of test material, percentage of components: 57.72% w/w copper
- Lot/batch No.: 31762/86
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Rabbits weighing 2.156 to 2.829 kg were acclimatised prior to dosing.
Test system
- Type of coverage:
- other: refer to details on study design.
- Preparation of test site:
- other: clipping.
- Vehicle:
- water
- Remarks:
- test material was moistened with distilled water.
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- 0.5 grams.
- Duration of treatment / exposure:
- 4 hours.
- Observation period:
- 72 hours.
- Number of animals:
- Six
- Details on study design:
- On the day prior to application, an area approximately 10 x 15 cm on the dorsal area of the trunk of each animal was clipped free of fur. On the day of application, 0.5 g of test material moistened with 0.5 mL distilled water was applied to the intact skin on the left side of each rabbit on a gauze patch. The patch was held in place by a waterproof plaster wrapped around the trunk. The right side of each animal was treated in the same way with a patch with 0.5 mL of distilled water only. Elizabethan collars were fitted to all animals. After 4 hours, the dressings were removed and the treated sites gently washed to remove any residual test substance.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- Following application of copper oxychloride, slight erythema (score 1) was noted in one animal after 30 minutes, and in two animals after 1 and 24 hours. No erythema was recorded after 48 or 72 hours. The mean score (24 to 72 hours) was 0.1. No oedema was recorded. The results are summarised in Table 1. The results of the distilled water only treatment are not presented in the report.
- Other effects:
- None.
Any other information on results incl. tables
Table 1. summary of individual and mean skin irritation scores according to Draize
Assessment time |
Scores according to Draize for animal number |
|||||
1 |
3 |
5 |
7 |
9 |
11 |
|
Erythema |
||||||
30 mins. |
1 |
0 |
0 |
0 |
0 |
0 |
1 hour |
1 |
0 |
0 |
0 |
1 |
0 |
24 hours |
1 |
0 |
0 |
1 |
0 |
0 |
48 hours |
0 |
0 |
0 |
0 |
0 |
0 |
72 hours |
0 |
0 |
0 |
0 |
0 |
0 |
Mean score per animal 24 - 72 hours |
0.3 |
0 |
0 |
0.3 |
0 |
0 |
Mean score all animals 24 -72 hours |
0.1 |
|||||
Oedema |
||||||
30 mins. |
0 |
0 |
0 |
0 |
0 |
0 |
1 hour |
0 |
0 |
0 |
0 |
0 |
0 |
24 hours |
0 |
0 |
0 |
0 |
0 |
0 |
48 hours |
0 |
0 |
0 |
0 |
0 |
0 |
72 hours |
0 |
0 |
0 |
0 |
0 |
0 |
Mean score per animal 24 - 72 hours |
0 |
0 |
0 |
0 |
0 |
0 |
Mean score all animals 24 - 72 hours |
0.0 |
|||||
|
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dicopper chloride trihydroxide was slightly irritating to rabbit skin (mean scores for all animals at 24 to 72 hours for erythema and oedema were 0.1 and 0.0, respectively.
Classification according to Directive 67/548/EEC: Not classified.
Classification according to CLP/GHS: Not classified. - Executive summary:
A GLP-compliant study was conducted in accordance with the requirements of EC Guideline B.4, OECD 404 and US EPA 40 CFR Section 798.4470 without significant deviation. Dicopper chloride trihydroxide was moistened with distilled water prior to application. Six female New Zealand white rabbits weighing 2.156 to 2.829 kg were acclimatised prior to dosing. On the day prior to application, an area approximately 10 x 15 cm on the dorsal area of the trunk of each animal was clipped free of fur. On the day of application, 0.5 g of test material moistened with 0.5 mL distilled water was applied to the intact skin on the left side of each rabbit on a gauze patch. The patch was held in place by a waterproof plaster wrapped around the trunk. The right side of each animal was treated in the same way with a patch with 0.5 mL of distilled water only. Elizabethan collars were fitted to all animals. After 4 hours, the dressings were removed and the treated sites gently washed to remove any residual test substance. Animals were examined for signs of irritation after 30 and 60 minutes, and after 24, 48 and 72 hours, and effects scored according to Draize.
Following application of dicopper chloride trihydroxide, slight erythema (score 1) was noted in one animal after 30 minutes, and in two animals after 1 and 24 hours. No erythema was recorded after 48 or 72 hours. The mean score across all animals (24 to 72 hours) was 0.1. No oedema was recorded. Dicopper chloride oxychloride is not classified as a skin irritant.
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