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EC number: 201-247-9 | CAS number: 80-07-9
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Toxicological Summary
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Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to OECD guideline with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (analytical purity not reported)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(4-chlorophenyl) sulphone
- EC Number:
- 201-247-9
- EC Name:
- Bis(4-chlorophenyl) sulphone
- Cas Number:
- 80-07-9
- Molecular formula:
- C12H8Cl2O2S
- IUPAC Name:
- 1-chloro-4-(4-chlorobenzenesulfonyl)benzene
- Details on test material:
- - Name of test material: 4,4'-dichlorodiphenyl sulfone (DCDPS)
- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Herilan Mrh-Haltung, H. Eggermann KG
- Mean body weight at study initiation: males 193 g (190-200 g) females 153 g (150-160 g)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
Concentration in vehicle: 50 %
DOSE VOLUME APPLIED:
7.67 mL/kg bw (3830 mg/kg bw)
10.0 mL/kg bw (5000 mg/kg bw)
13.62 mL/kg bw (6810 mg/kg bw) - Doses:
- 3830, 5000 and 6810 mg/kg bw
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: several times on the day of application and daily thereafter. Body weights were recorded on days 2-4, 7 and 13 post application.
- Necropsy of all survivors was performed. - Statistics:
- Finney DJ (1971). Probit analysis (3rd edition). Cambridge University Press, Cambridge, UK.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 189 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 376 - 6 303
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 400 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 810 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality incidences for male (m) and female (f) rats were:
3830 mg/kg bw: 0/5 (m), 2/5 (f), 2/10 (total)
5000 mg/kg bw: 1/5 (m), 2/5 (f), 3/10 (total)
6810 mg/kg bw: 5/5 (m), 4/5 (f), 9/10 (total) - Clinical signs:
- other: The clinical signs observed were dyspnoea, apathy, aggressiveness, staggering, spastic gait, ruffled fur, alopecia, sticky muzzle, sticky eyes and poor condition.
- Gross pathology:
- Deceased animals: acute dilatation in the right auricle and hyperaemia in the heart, haemorrhagic ulceration in the stomach, pale kidneys, degenerative changes in lobes of liver (1 animal).
Sacrificed animals: no macroscopical findings.
Applicant's summary and conclusion
- Executive summary:
In this acute oral toxicity study (BASF AG, 1981), Sprague-Dawley rats (5 rats/sex/dose level) were given a single oral dose (gavage) of DCDPS in olive oil (50 % a.i.) at dose levels of 3850, 5000 or 6810 mg/kg. Animals were then observed for mortality, body weight changes and clinical signs of toxicity for 14 days. All surviving animals were subjected to necropsy at the end of the treatment period.
The oral LD50 was 5189 mg/kg bw (males: 5400 mg/kg bw; females: 4810 mg/kg bw) under the conditions of this study. DCDPS is of low acute oral toxicity based on this LD50.
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