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EC number: 201-247-9 | CAS number: 80-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study, similar to test guideline OECD 401.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 401
- Deviations:
- yes
- Remarks:
- (i.p. administration, 7-days observation period, no necropsies)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Bis(4-chlorophenyl) sulphone
- EC Number:
- 201-247-9
- EC Name:
- Bis(4-chlorophenyl) sulphone
- Cas Number:
- 80-07-9
- Molecular formula:
- C12H8Cl2O2S
- IUPAC Name:
- 1-chloro-4-(4-chlorobenzenesulfonyl)benzene
- Details on test material:
- - Name of test material: 4,4'-dichlorodiphenylsulfone (DCDPS)
- Physical state: white powder
- Storage condition: at room temperature, protected from light
- Test item sample received on 02-Jan-1989
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague Dawley Inc, Frederick, MD, USA
- Age at study initiation: 6-8 weeks old
- Weight at study initiation: males 27-37 g, females 22-28 g
- Housing: in groups of max. 5 animals/cage, in autoclavable plastic cages with filter tops
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 74 ±6 °F (23.3 ± 3.4 °C)
- Humidity: 50 ± 20 %
- Photoperiod: 12 hours dark / 12 hours light
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Details on exposure:
- Single intraperitoneal injection
- Doses:
- 500, 1000, 1500, 2000, 2500 or 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 7 days
- Weighing: once prior to dosing and on days 1 and 3
- Necropsy of survivors performed: no - Statistics:
- Probit analysis
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 448 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The mortality incidences noted in males (m) and females (f) during the 7-days observation period were as follows:
0/5 (m), 0/5 (f) in controls and at 500 and 1000 mg/kg bw
1/5 (m), 2/5 (f) at 1500 mg/kg bw
3/4 (m), 2/5 (f) at 2000 mg/kg bw
5/5 (m), 4/5 (f) at 2500 mg/kg bw
4/5 (m), 4/5 (f) at 5000 mg/kg bw - Clinical signs:
- Head tilt, running in circles, lethargy, piloerection, hunched posture and/or cloudy eyes were noted at 1500 mg/kg bw and/or at higher dose levels.
- Body weight:
- In treated mice, dose-dependent decreases in body weight were noted as compared to pre-treatment body weights.
- Gross pathology:
- Not determined
Applicant's summary and conclusion
- Executive summary:
This acute toxicity study (Microbiological Associates Inc., 1991) was performed as a preliminary test in order to set dose levels for a micronucleus test (see section 7.6.2).
Young adult ICR mice (5 mice/sex/dose level) were treated by intraperitoneal injection of DCDPS in corn oil at dose levels of 0 (vehicle control), 500, 1000, 1500, 2000, 2500 or 5000 mg/kg bw. Dose-dependant mortality was noted in both sexes at 1500 to 5000 mg/kg bw during the 7 -days observation period. Male and female animals treated at 1500 mg/kg bw or higher dose levels showed head tilt, running in circles, lethargy, piloerection, hunched posture and or cloudy eyes. Dose-dependent decreases in body weight were noted in treated mice as compared to pre-treatment body weights.
The LD50 value for the intraperitoneal route was 2448 mg/kg bw. Based on this LD50 value, DCDPS dislays low acute toxicity following intraperitoneal exposure.
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