Registration Dossier
Registration Dossier
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EC number: 203-404-7 | CAS number: 106-50-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 72-h ErC50 and ErC10 values in freshwater green algae are 0.270 mg/L and 0.071 mg/L, respectively.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.27 mg/L
- EC10 or NOEC for freshwater algae:
- 0.071 mg/L
Additional information
A total of three algae studies are available for evaluation. All were conducted in accordance with or equivalent to generally accepted guidelines and in compliance with GLP criteria. Two older algae studies are available and were already included in the REACH dossier submitted in 2010 (Japan Food Search Laboratories, 2002; Enseco Inc., 1986). The third algae study was performed more recently to get a better understanding of the behavior of the test substance in the test medium by testing more concentrations and by additional sampling for analytical monitoring of test substance concentrations (Dr. Noack Laboratorien, 2013). Although from this study no NOEC value could be calculated (effect noted at lowest test concentration), an ErC10 value was calculated. The older studies should not be disregarded in evaluation of algae toxicity. Despite limited sampling regimes and limitations in reporting of test substance analysis, in both studies a concentration-dependent increase in toxicity is reported. Altogether, the additional efforts taken in the most recent study to quantify test substance concentrations, and the availability of a statistically determined chronic value (ErC10), give this study a slight advantage over the older ones. Therefore, the 72-h ErC50 of 0.270 mg/L and the ErC10 value of 0.071 mg/L from the most recent study are considered directly for assessment.
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