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EC number: 203-404-7 | CAS number: 106-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study was not conducted under GLP; only 1 sex (males); no environmental or exposure apparatus details reported; frequency of observations and weights not reported. This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labeling and/or risk assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Only males were tested; no environmental conditions, exposure apparatus details, or frequency of observations or weights reported
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- - Purity: 99.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD®
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7-8 weeks old
- Weight at study initiation: 236-272 g
- Fasting period before study: None
- Housing: Animals were housed in pairs in stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: At least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
Administration / exposure
- Route of administration:
- other: vapor at <0.54 mg/L; aerosol at ≥0.54 mg/L
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Not reported
- Exposure chamber volume: Not reported
- Method of holding animals in test chamber: Not reported
- Source and rate of air: Not reported
- Method of conditioning air: Not reported
- System of generating particulates/aerosols: The test material was heated (115-189ºC) in a round bottom flask. Heated nitrogen (53-70ºC) was blown through the flask, sweeping test substance vapors into a dilution air stream. Prior to chamber entry, oxygen was added to the mixture.
- Treatment of exhaust air: Not reported
- Temperature, humidity, pressure in air chamber: ≤35°C; humidity and pressure not reported; oxygen greater than or equal to 20%
TEST ATMOSPHERE
- Brief description of analytical method used: Test atmospheres were sampled by drawing chamber atmosphere through a fritted glass impinger containing methanol as the trapping solvent. The frit was immersed in the methanol. If the airflow stopped (completion of sampling), the frit filled with methanol (the trapping agent). Samples were analyzed by a GC equipped with a flame ionization detector. Samples were chromatographed isothermally at 130ºC on a glass column packed with 3% OV-17 on 80/100 mesh Chromosorb® W. Sample concentrations were determined by comparison with a standard cure.
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0.07, 0.30, 0.54, 0.94, or 1.8 mg/L
- No. of animals per sex per dose:
- 10 male rats/concentration
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: No - Statistics:
- The LC50 was calculated by the method of Finney.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 0.92 mg/L air
- 95% CL:
- 0.59 - 1.9
- Exp. duration:
- 4 h
- Mortality:
- No deaths at 0.07 mg/L, 1/10 deaths at 0.30 mg/L, 4/10 deaths at 0.54 mg/L, 5/10 deaths at 0.94 mg/L, 7/10 deaths at 1.8 mg/L. All deaths occurred within 48 hours.
- Clinical signs:
- other: During exposure: No overt signs at 0.07 mg/L. At higher concentrations rats showed red nasal discharge. Cyanosis was observed at 1.8 mg/L. During 14 day observation: At all concentrations rats showed red ocular discharge or brown-stained fur around the
- Body weight:
- In a dose-dependent fashion, slight to severe weight loss for 3 days followed by weight gain was observed.
Applicant's summary and conclusion
- Interpretation of results:
- moderately toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- This study and the conclusions which are drawn from it fulfill the quality criteria (validity, reliability, repeatability). LC50 (rats) = 0.92 mg/L
- Executive summary:
An inhalation medial lethal concentration (LC50) for the test substance was determined in male Crl:CD®rats given single 4-hour exposures. The calculated LC50 is 0.92 mg/L with 95% confidence limits of 0.59 and 1.9 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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