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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Reliable with severe restrictions. Non GLP. Not a standard guideline method. Limited scope. Limited information in materials, methods, and interpretation of results. Only one dose group tested. Only observed enzymatic activity in the skin without evaluation of other parameters such as body weight, clinical observations, irritation, histopathology, etc.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1992

Materials and methods

Principles of method if other than guideline:
Guinea pigs were treated dermally with the test substance for 15 or 30 days.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Details on test material:
- Purity: 99%

Test animals

Species:
guinea pig
Strain:
other: albino
Sex:
male

Administration / exposure

Type of coverage:
open
Vehicle:
ethanol
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
15 and 30 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 mL of a 3% solution
Basis:
nominal per unit body weight
No. of animals per sex per dose:
10 males per group
Control animals:
yes, concurrent vehicle

Results and discussion

Effect levels

Sex:
male
Basis for effect level:
other: see 'Remark'
Remarks on result:
not measured/tested
Remarks:
Effect level not specified (migrated information)

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The results of the study suggest that industrial workers or populations who are exposed to the test substance are likely to suffer from dermal toxicity due to penetration of test substance.
Executive summary:

Guinea pigs were treated dermally with the test substance for 15 or 30 days. Treatment resulted in higher activity levels of ACP at day 15 and 30. Beta-glucuronidase was also elevated at both intervals. ALP was increased only at day 30. Histidase and tyrosinase were elevated at day 30. The GSH contents did not show any alterations, whereas LPO was elevated at day 30. Histamine content was elevated at both time points. No mortality was observed.