Allyl 2,3-epoxypropyl ether

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given, acceptable with restrictions (The study was performed before the establishment of GLP and OECD guidelines.)

Data source

Reference

Reference 1

Reference Type:

publication

Title:

The toxicology of Glycidol and some Glycidyl Ethers.

Author:

Hine CH et al.

Year:

1956

Bibliographic source:

Report, Department of Pharmacology and Experimental Therapeutics, University of California School of Medicine, San Francisco. Cited in OECD SIDS (SIAM 25, October 2007, Helsinki)

Reference 2

Reference Type:

publication

Title:

The toxicology of Glycidol and some Glycidyl Ethers.

Author:

Hine CH, Kodama JK, Wellington JS, Dunlap MK and Anderson HH

Year:

1956

Bibliographic source:

A.M.A. Archives of Industrial Health. 14: 250-264. Cited in OECD SIDS (SIAM 25, October 2007, Helsinki)

Reference 3

Reference Type:

publication

Title:

The toxicology of glycol and some glycidyl ethers.

Author:

Shell Chemical Company

Year:

1956

Bibliographic source:

TSCATS, OTS0523687, New Doc ID 40-5640496, Date produced 3/18/56.

Materials and methods

Principles of method if other than guideline:

Four groups of 3 male rabbits were exposed to the test substance under occlusive conditions at dose rates of 730, 1450, 2900 and 5800 mg/kg bw. The volume of administration as well as the area covered was not mentioned. Clinial signs and mortalities were observed for 10 days. At the end of observation period, all animals were sacrificed and necropsy was performed.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Allyl 2,3-epoxypropyl ether

EC Number:

203-442-4

EC Name:

Allyl 2,3-epoxypropyl ether

Cas Number:

106-92-3

Molecular formula:

C6H10O2

IUPAC Name:

2-[(prop-2-en-1-yloxy)methyl]oxirane

Details on test material:

- Name of test material (as cited in study report): Allyl Glycidyl Ether

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Simonson laboratory in Gilroy, California
- Weight at study initiation: 2-2.5 kg
- Diet (e.g. ad libitum): standards rabbit pellets

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: no data

Duration of exposure:

7 h

Doses:

730, 1450, 2900 and 5800 mg/kg b.w.

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 10 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology

Statistics:

Method of Weil (Biometrics, 3: 249-268, 1952)

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

2 550 mg/kg bw

Mortality:

0/3, 0/3, 2/3 and 3/3 animals died at doses of 730, 1450, 2900 and 5800 mg/kg bw, respectively. The death occured at 7, 5.5-7 hours at the dose levels of 2900 and 5800 mg/kg bw, respectively.

Clinical signs:

other: Reactions to percutaneous treatment were minimal, with varying degrees of skin irritation. Depression increased during the 7 hours of immobilization. 

Gross pathology:

Necropsy showed constricted kidneys and spleens.

Other findings:

- Histopathology: microscopic examination of tissues of 2 rabbits was normal.