Registration Dossier
Registration Dossier
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EC number: 203-442-4 | CAS number: 106-92-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable with restrictions (The study was performed before the establishment of GLP and OECD guidelines.)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The toxicology of Glycidol and some Glycidyl Ethers.
- Author:
- Hine CH et al.
- Year:
- 1 956
- Bibliographic source:
- Report, Department of Pharmacology and Experimental Therapeutics, University of California School of Medicine, San Francisco. Cited in OECD SIDS (SIAM 25, October 2007, Helsinki)
- Reference Type:
- publication
- Title:
- The toxicology of Glycidol and some Glycidyl Ethers.
- Author:
- Hine CH, Kodama JK, Wellington JS, Dunlap MK and Anderson HH
- Year:
- 1 956
- Bibliographic source:
- A.M.A. Archives of Industrial Health. 14: 250-264. Cited in OECD SIDS (SIAM 25, October 2007, Helsinki)
- Reference Type:
- publication
- Title:
- The toxicology of glycol and some glycidyl ethers.
- Author:
- Shell Chemical Company
- Year:
- 1 956
- Bibliographic source:
- TSCATS, OTS0523687, New Doc ID 40-5640496, Date produced 3/18/56.
Materials and methods
- Principles of method if other than guideline:
- According to the method of Draize JH (Food Drug & Cosmetics Law J. 10: 722-732, 1955)
- GLP compliance:
- no
Test material
- Reference substance name:
- Allyl 2,3-epoxypropyl ether
- EC Number:
- 203-442-4
- EC Name:
- Allyl 2,3-epoxypropyl ether
- Cas Number:
- 106-92-3
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 2-[(prop-2-en-1-yloxy)methyl]oxirane
- Details on test material:
- - Name of test material (as cited in study report): Allyl Glycidyl Ether
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Simonson laboratory in Gilroy, California
- Weight at study initiation: 2-3 kg
- Diet (e.g. ad libitum): standards rabbit pellets
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 72 h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: not reported
- The back and flanks of rabbits were clipped 24 h prior to use. The shoulder and hips were used as test sites, two areas on each animal being scarified and two intact. Scarification was accomplished by making four intersecting epidermal scratches, each about 2 cm long, with a scalpel blade. A patch consisting of three layers of gauze was secured over each area with adhesive tape, and undiluted compound was introduced under the gauze. The rabbits were wrapped in towels and immobilized for 24 h, after which the areas were examined and irritation scores noted.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM: according to Draize JH (1955)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- Intact skin
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: see free text for individual scores
- Irritation parameter:
- edema score
- Remarks:
- Intact skin
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 1.83
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: see free text for individual scores
Any other information on results incl. tables
Irritation scores
Animal No. |
Time period (h) |
Scarified skin |
Intact skin |
||
Erythema |
Edema |
Erythema |
Edema |
||
1 |
24 |
2 |
1 |
1 |
4 |
72 |
3 |
2 |
2 |
2 |
|
2 |
24 |
4 |
1 |
3 |
0 |
72 |
4 |
4 |
0 |
0 |
|
3 |
24 |
1 |
3 |
1 |
3 |
72 |
2 |
4 |
1 |
2 |
|
1 |
Mean (24-72 h) |
2.5 |
1.5 |
1.5 |
3.0 |
2 |
Mean (24-72 h) |
4.0 |
2.5 |
1.5 |
0.0 |
3 |
Mean (24-72 h) |
1.5 |
3.5 |
1.0 |
2.5 |
1-3 |
Total mean |
2.67 |
2.50 |
1.33 |
1.83 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
