Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-442-4 | CAS number: 106-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: fertility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to OECD guideline 422, acceptable with restrictions (only 8 weeks exposure instead of 70 days, only a summary of the results available)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology and carcinogenesis studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel rats and B6C3F1 Mice (inhalation studies).
- Author:
- National Toxicology Program (NTP)
- Year:
- 1 990
- Bibliographic source:
- NTP Technical Report 376, NIH Publication No. 90-2831, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- yes
- Remarks:
- only 8 weeks (56 days) exposure instead of 70 days, only a summary of the results available
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Allyl 2,3-epoxypropyl ether
- EC Number:
- 203-442-4
- EC Name:
- Allyl 2,3-epoxypropyl ether
- Cas Number:
- 106-92-3
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 2-[(prop-2-en-1-yloxy)methyl]oxirane
- Details on test material:
- - Name of test material (as cited in study report): Allyl Glycidyl Ether
- Physical state: clear colorless liquid
- Analytical purity: 99 %
- Lot/batch No.: E337MO
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CAMM Research Institute (Wayne, NJ)
- Age at study initiation: 8 weeks
- Weight at study initiation (mean weight): male 234-269 g, females 177-187 g
- Diet (e.g. ad libitum): NIH 07 Rat and Mouse Ration (Zeigler Bros., Inc., Gardners, PA)
- Water (e.g. ad libitum): Automatic watering system
- Acclimation period: 21 days
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Vapor Generation System: No additional preparation of the liquid allyl glycidyl ether (AGE) was necessary before introduction into the vapor generation system. The liquid was pumped from a stainless steel reservoir to a vaporizer by a stable micrometering pump with adjustable pump rates.
- Temperature, humidity in air chamber: 20.6-26.7 °C, 32-75%
TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatography with a flame ionization detector
- Samples taken from breathing zone: yes - Details on mating procedure:
- - M/F ratio per cage: 1:1
- Length of cohabitation: 7 days
- Proof of pregnancy: sperm in vaginal smear day 0 of pregnancy - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- - Actual concentrations: Not indicated; in most instances, the vapor concentrations were within 10 % of the nominal concentrations
- Stability: No significant decomposition was observed
- Homogeneity: homogeneous distribution of the vapor - Duration of treatment / exposure:
- 8 weeks
- Frequency of treatment:
- 6 hours/day, 5 days/week
- Details on study schedule:
- - Parental animals (P) were mated until 2 days after the end of the 8 week exposure period: control animals with control animals, exposed males with control females and control males with exposed females.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 30, 100 and 200 ppm (equivalent to 0, 140, 467, 934 mg/m3)
Basis:
- No. of animals per sex per dose:
- 20
- Control animals:
- yes, sham-exposed
Examinations
- Parental animals: Observations and examinations:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: twice daily
- Cage side observations checked: clinical signs / mortality
BODY WEIGHT: Yes
- Time schedule for examinations: animal weights were recorded before the studies, once per week, and at necropsy.
FOOD CONSUMPTION: no - Oestrous cyclicity (parental animals):
- not performed
- Sperm parameters (parental animals):
- Parameters examined in [P] male parental generations: sperm count, sperm motility and abnormalities (8 males/dose level)
- Litter observations:
- PARAMETERS EXAMINED
The following parameters were examined in F1 offspring:
- Clinical observations / mortality: daily
- Body weights: immediately after birth and at 4 and 21 days old
- Sex: immediately after birth and on day 4 and 21 post partum
Number of male pups examined were 6, 1-2, 0 and 1 at 0, 30, 100 and 200 ppm, respectively; females examined were 6, 9-10, 10 and 9 at 0, 30, 100 and 200 pp, respectively. - Postmortem examinations (parental animals):
- GROSS NECROPSY
- Gross necropsy was performed according to standard protocol (not further specified)
HISTOPATHOLOGY / ORGAN WEIGHTS: not performed - Postmortem examinations (offspring):
- GROSS NECROPSY
- Macroscopic observations: checked for external abnormalities (not further specified; 9 foetuses/2 litters at 30 ppm and 8 foetuses/1 litter at 200 ppm examined)
HISTOPATHOLOGY / ORGAN WEIGTHS: not performed - Statistics:
- Dunnett's test (Dunnett, 1980), Fisher exact test
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- not specified
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Organ weight findings including organ / body weight ratios:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- not examined
- Reproductive function: sperm measures:
- effects observed, treatment-related
- Reproductive performance:
- effects observed, treatment-related
Details on results (P0)
BODY WEIGHT AND FOOD CONSUMPTION (PARENTAL ANIMALS): A decrease body weight gain was seen in males (82 and 70% of control) and females (92 and 86% of control) at 100 and 200 ppm at the end of exposure. At termination female body weight had recovered, while male body weights were still reduced at all dose levels (90, 89 and 84% of control at 30, 100 and 200 ppm, respectively).
REPRODUCTIVE FUNCTION: SPERM MEASURES (PARENTAL ANIMALS): no significant effects were seen on motility or the number of sperms. The percentage of abnormal sperms present at 200 ppm was statistically significant increased (1.11 to 0.64% in the control). Males were killed 13-14 days after the last exposure to the test substance and sperm were counted and examined for motility and for abnormalities. Therefore, reversible effects on sperm cells might have disappeared.
REPRODUCTIVE PERFORMANCE (PARENTAL ANIMALS):
- Mating rate (copulation detected): no effect was observed
- Number of females impregnated:
Exposed males with control females: decreased at 30, 100 and 200 ppm (15/20, 9/20, 4/20 and 1/18 at 0, 30, 100 and 200 ppm, respectively);
Control males with exposed females: no effect was observed (15/20, 19/20, 20/20 and 17/20 at 0, 30, 100 and 200 ppm)
- Duration of gestation: no effect was observed
- Implantation sites/dam (day 19 of gestation):
Exposed males with control females: 15.0, 5.7 and 5.2 at 0, 30 and 100 ppm, respectively;
Control males with exposed females: no effect observed
- No. of litters (on day 19 of gestation or within 24 hours after birth):
Exposed males with control females: 15, 9, 4 and 1 at 0, 30, 100 and 200 ppm;
Control males with exposed females: 15, 19, 19 and 17 at 0, 30, 100 and 200 ppm, respectively
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEC
- Remarks:
- toxicity
- Effect level:
- 140 mg/m³ air
- Sex:
- male
- Basis for effect level:
- other: decreased body weight gain at 467 mg/m3
- Dose descriptor:
- NOAEC
- Remarks:
- fertility
- Effect level:
- < 140 mg/m³ air
- Sex:
- male
- Basis for effect level:
- other: decreased pregnant females and the lower pups viability index
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- not specified
- Mortality / viability:
- mortality observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Sexual maturation:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Histopathological findings:
- not examined
Details on results (F1)
- Percentage survival on day 4 (exposed males with control females): 77 and 33 at 0 and 30 ppm, respectively (the litters were too small by 100 and 200 ppm to calculate a viability index);
- Percentage survival on day 4 (control males with exposed females): no effect observed.
- Pups alive on day 21 per pups alive on day 4: no effects observed
- Litter size (exposed males with control females): 14, 6, 5 and 8 at 0, 30, 100 and 200 ppm, respectively;
- Litter size (control males with exposed females): 14, 13, 13 and 12 at 0, 30, 100 and 200 ppm, respectively
BODY WEIGHT (OFFSPRING): no effect was observed
SEXUAL MATURATION (OFFSPRING)
- Sex ratio: no effect observed
GROSS PATHOLOGY (OFFSPRING)
- External abnormalities: no treatment-related effects observed
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Summary of reproductive performance of rats after inhalation exposure for eight weeks to Allyl Glycidyl Ether
Conc. (ppm) |
Results when males were exposed (a) |
Results when females were exposed (b) |
||||||
Copulations detected (c) |
No. of females impregnated |
No. of litters (d) |
Total pups/ litter (e) |
Copulations detected (c) |
No. of females impregnated |
No. of litters (d) |
Total pups/ litter (e) |
|
0 |
15/20 |
15 |
15 |
13.8±2.2 |
15/20 |
15 |
15 |
13.8±2.2 |
30 |
18/20 |
9 |
9 |
5.9±4.9 |
17/20 |
19 |
19 |
13.0±2.1 |
100 |
17/20 |
4 |
4 |
5.3±4.9 |
19/20 |
20 |
19 |
12.7±2.4 |
200 |
14/18 |
1 |
1 |
8.0 |
15/20 |
17 |
17 |
12.1±1.5 |
(a) Data from control females mated with exposed males
(b) Data from exposed females mated with control males
(c) Number of copulations detected/number of females
(d) Litters examined at d 19 of gestation or within 24 h after birth
(e) Mean ± standard deviation
Reproductive status of maternal rats and postnatal survival of offspring of rats exposed for eight weeks (before mating) to Allyl Glycidyl Ether by inhalation
Parameters examined |
control |
30 ppm |
100 ppm |
200 ppm |
||||
No.(a) |
Mean(b) |
No.(a) |
Mean(b) |
No.(a) |
Mean(b) |
No.(a) |
Mean(b) |
|
Results when males were exposed (c) |
||||||||
Length of gestation (days) |
7 |
23.1±0.9 |
3 |
23.7±0.6 |
0 |
- |
1 |
23.0 |
Implantation sites per dam |
7 |
14.0±4.6 |
5 |
6.4±5.7* |
0 |
- |
1 |
10.0 |
Pups alive on day 1 |
7 |
11.6±5.5 |
3 |
6.3±4.0 |
0 |
- |
1 |
8.0 |
Pups alive on day 4 |
7 |
8.9±4.7 |
3 |
0.7±1.2 |
0 |
- |
1 |
8.0 |
Pups alive on day 21 |
7 |
8.9±4.7 |
3 |
0.7±1.2 |
0 |
- |
1 |
8.0 |
Results when females were exposed (c) |
||||||||
Length of gestation (days) |
7 |
23.1±0.9 |
8 |
22.6±0.7 |
9 |
22.8±0.4 |
7 |
22.7±0.5 |
Implantation sites per dam |
7 |
14.0±4.6 |
10 |
15.0±1.9 |
10 |
14.4±1.7 |
9 |
13.6±1.1 |
Pups alive on day 1 |
7 |
11.6±5.5 |
10 |
12.4±2.1 |
10 |
12.7±2.7 |
9 |
12.1±1.4 |
Pups alive on day 4 |
7 |
8.9±4.7 |
10 |
11.3±4.1 |
10 |
11.1±4.0 |
9 |
11.9±1.5 |
Pups alive on day 21 |
7 |
8.9±4.7 |
10 |
11.2±4.2 |
10 |
1.1±4.0 |
9 |
11.9±1.5 |
(a) Number of dams or litters
(b) Mean ± standard deviation
(c) Control female rats were mated with exposed male rats.
(d) Exposed female rats were mated with control male rats.
*P<0.05 vs. the controls by Dunnett’s test
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.