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EC number: 220-329-5 | CAS number: 2720-73-2
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: earthworm
- Animal group:
- other: QSAR model
- Study type:
- other: QSAR
- Substrate type:
- other: QSAR
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Moisture:
- not applicable. QSAR model
- Details on test conditions:
- 100% Potassium amyl xanthate (CAS No. 2720-73-2)
SMILES : S=C(S(K))OCCCCC
CHEM : Carbonodithioic acid, O-pentyl ester, potassium salt
MOL FOR: C6 H11 O1 S2 K1
MOL WT : 202.37
Log Kow: 2.34 (KowWin estimate)
Wat Sol: 655.8 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 263.311 mg/kg soil ww
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
- Details on results:
- LC50 (14-day, earthworm)= 263.311 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 263.311 mg/kg soil dw - Reported statistics and error estimates:
- US EPA accepted QSAR method for chemicals properties assessment.
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- LC50 (14-day, earthworm)= 263.311 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=263.311 mg/kg soil dw - Executive summary:
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 263.311 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 263.311 mg/kg soil dw
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test substance was added to fresh pine litter substrate. pH and conductivity was measured during 6 months. At regular times the enchytraeids are counted both in the controls and in the test samples. Toxicity was estimated by calcuting the regression equation between reproduction number and pH or conductivity.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- - Concentrations: 0, 500, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000 mg/l
- Vehicle:
- no
- Test organisms (species):
- Enchytraeus sp.
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Source: Rijksuniversiteit Gent - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 180 d
- pH:
- 7.3 (init.) - 6.3 (fin.)
- Moisture:
- humidity was adjusted weekly with rainwater
- Details on test conditions:
- TEST SYSTEM
- Amount of soil or substrate: 3 g/l
- No. of replicates per treatment group:4
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
-Composition (if artificial substrate): fresh pine substrate
- pH=4.4
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : reproduction - Nominal and measured concentrations:
- - Nominal concentrations: 0, 500, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000 mg/l
- Reference substance (positive control):
- not specified
- Duration:
- 180 d
- Dose descriptor:
- EC50
- Effect conc.:
- 850 other: mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: population density
- Duration:
- 180 d
- Dose descriptor:
- other: EC92
- Effect conc.:
- 3 000 other: mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: population density
- Details on results:
- The values of LC50 and LC92 are calculated using the regression given in the method. The enchytraeid population was >95% Cognetia sphagnetorum.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 90d LC50 = 850 and LC92 = 3000 mg/l for the enchytraeid population in fresh pine substrate.
Potassium Hydroxide is used in the manufacturing process for Potassium amyl xanthate and is present in the final product. Therefore, the health effects of Potassium Hydroxide need to be considered in the assessment of potassium amyl xanthate.
Referenceopen allclose all
Overview of QSARs estimations on toxicity of Potassium amyl xanthate to soil macroorganisms
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
LC50 (14-day, earthworm)= 263.311 mg/L (ppm)
|
Reliable withrestrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
LC50 (14-day, earthworm)=263.311 mg/L (ppm)
The values of LC50 and LC92 are calculated using the regression given in the method. The enchytraeid population was >95% Cognetia sphagnetorum.
Description of key information
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 263.311 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 263.311 mg/kg soil dw
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 263.311 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 52.7 mg/kg soil dw
Additional information
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 263.311 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 263.311 mg/kg soil dw
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