Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953
Reference Type:
secondary source
Title:
Unnamed
Report date:
1953

Materials and methods

Principles of method if other than guideline:
BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Triisobutyl phosphate
EC Number:
204-798-3
EC Name:
Triisobutyl phosphate
Cas Number:
126-71-6
Molecular formula:
C12H27O4P
IUPAC Name:
triisobutyl phosphate

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
other: Pfefferminztee (in der Traenke)
Duration of treatment / exposure:
51 Tage
Frequency of treatment:
taeglich
Doses / concentrations
Dose / conc.:
6 316 ppm
Remarks:
according to 430-440 mg/kg/day; m-w
Control animals:
yes, concurrent vehicle
Details on study design:
Post-exposure period: keine Angabe

Results and discussion

Results of examinations

Details on results:
Kein Einfluss auf die Koerpergewichtsentwicklung, vermehrtes Auftreten von "Nierenreizungen" im Vergleich zur Kontrollgruppe (wird von den Autoren als belanglos bezeichnet).

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
other: not determined

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion