Registration Dossier
Registration Dossier
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EC number: 269-682-7 | CAS number: 68309-95-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The substance has given a clear negative result in a Magnusson & Kligman maximisation study in the guinea pig (0/17 sensitisation) rate.
There is no evidence of sensitisation in humans based on experience in use.
Migrated from Short description of key information:
A GLP-compliant Magnusson & Kligman maximisation study according to OECD Guideline 406 has been conducted. Concentrations used for induction were 10% in distilled water for the injections, and 100% for the topical application (preceded by wetting with 10% aqueous SLS to create local irritation). Following challenge with Ammonium Zirconium Carbonate at a concentration of 100%, none of the 17 test group animals showed positive reactions to this application.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No specific test data is available on respiratory sensitisation but experience in use suggests the substance is not a respiratory sensitiser.
Migrated from Short description of key information:
No specific test data is available on respiratory sensitisation but the substance has been used in industry without any incidences of respiratory sensitisation for many years.
Justification for classification or non-classification
The substance has given a clear negative result in a Magnusson & Kligman maximisation study in the guinea pig (0/17 sensitisation) rate.
There is no evidence of sensitisation in humans based on experience in use. On this basis the substance is not classified as a skin sensitiser.
No specific test data is available on respiratory sensitisation but experience in use suggests the substance is not a respiratory sensitiser
and hence no classification is required.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
