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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
21.01.-26-02.2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Parameters determined according EC test guideline according GLP guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
yes
Remarks:
Due to the physical-chemical properties of the test item it is impossible to investigate its hydrolytic propertiesaccording to the EU Commision Regulation (EC) No. 440/2008C.7. According to literature, in auqeous solution stannic chloride is cleaved by hy
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Tin tetrachloride
EC Number:
231-588-9
EC Name:
Tin tetrachloride
Cas Number:
7646-78-8
Molecular formula:
Cl4Sn
IUPAC Name:
tin tetrachloride
Details on test material:
Batch No.: 16.02.2009
Purity: 99.9 %
Radiolabelling:
no

Results and discussion

Preliminary study:
Because of the difficult handling and high instability of the test item the performance of the hydrolysis test described in the European Commission Regulation (EC)440/2008 C.7 and in the OECD guideline 111 was modified. Nevertheless the observation made during the performance of the test and the calculations showed that in distilled water 90 -96 % of the test item was hydrolized after a time period of 2.5 h. Therefore the tested substance has to be considered as hydrolytically unstable and according to the guidelines no additional testing is required.
Test performance:
No additional testing required.
Transformation products:
yes
Identity of transformation productsopen allclose all
No.:
#1
Reference
Reference substance name:
Unnamed
IUPAC name:
Hydrogen chloride
Inventory number:
InventoryMultipleMappingImpl [inventoryEntryValue=EC 231-595-7]
CAS number:
7647-01-0
Identity:
Other names: Hydrochloric Acid; Aqueous hydrochloric acid; Anhydrous hydrochloric acid; Basilin; Chlorohydric acid; Hydrochloric acid gas; Hydrochloride; Muriatic acid; Salzsaeure; HCl; Hydrochloric acid, anhydrous; Hydrogen-chloride-anhydrous-; Acide chlorhydrique; Acido cloridrico; Chloorwaterstof; Chlorowodor; Chlorwasserstoff; NA 1789; Spirits of salt; UN 1050; UN 1789; UN 2186; Anhydrous hydrogen chloride; Hydrogen chloride (acid); Marine acid; Soldering acid; Spirit of salt; Spirits of salts
Molecular formula:
Cl H
Molecular weight:
36.461
SMILES notation:
Cl
InChl:
=1S/ClH/h1H
No.:
#2
Reference
Reference substance name:
Unnamed
IUPAC name:
18282-10-5 (tin oxide)
Identifier:
CAS number
Identity:
18282-10-5 (tin oxide)
Details on hydrolysis and appearance of transformation product(s):
2 test solutions were prepared with 100 ml of distilled water and app. 0.25 g of test item. The pH value if the water before the addition of the test item was 5.6. During the addition of stannic tetrachloride a reaction accompanied with the formation of fog could be observed and the test solution bubbled. For the time period of 2.5 h the pH value and the temperature of the test solutions were recorded. Immediately after the additon of the test item both solution reacheda pH-value of 1.6. This indicates a fast hydrolysis reaction of the test item with water at room temperature. As the pH remained constant for 2.5 h, it could be assumed that there is no further reaction. For the determination of the amount of hydrolysis product hydrochlorid acid the solutions were titrated with NaOH subsequently.
Dissipation DT50 of parent compound
Remarks on result:
other: Because of the difficult handling and high instability of the test item the performance of the hydrolysis test described in the European Commission Regulation (EC)440/2008 C.7 and in the OECD guideline 111 was modified.
Remarks:
Nevertheless the observation made during the performance of the test and the calculations showed that in distilled water 90-96 % of the test item was hydrolized after a time period of 2.5 h. Therefore the tested substance has to be considered as hydrolytically unstable and according to the guidelines no additional testing is required.

Applicant's summary and conclusion

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