Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No information whether study was conducted in accordance with GLP. Test performed with male animals only. Airflow rates through the inhala-tion equipment not reported. No necropsy or histopathological findings reported.

Data source

Reference Type:
other: OECD SIDS Dossier

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Tin tetrachloride
EC Number:
EC Name:
Tin tetrachloride
Cas Number:
Molecular formula:
tin tetrachloride
Test material form:
Details on test material:
Tin Tetrachloride [CAS No. 7646-78-8]; >99% purity, source: Aldrich Chemical Co.

Results and discussion

Any other information on results incl. tables

Mortality (number of animals dead/total number tested), by mean dose level:
0.29 mg/l: 0/10 animals
0.67 mg/l: 3/10 animals (all deaths during exposure)
0.97 mg/l: 4/10 animals (2 deaths during exposure; 1 @ 24 h; 1 @ 6 d)
1.01 mg/l: 1/10 animals (death during exposure)
1.37 mg/l: 3/10 animals (all deaths during exposure)
1.77 mg/l: 7/10 animals (5 deaths during exposure; 1 overnight; 1 not reported)
3.08 mg/l: 10/10 animals (8 deaths during exposure; 1 overnight; 1 @ 48 h)

Test substance vapors formed a white cloud upon contact with the humidified air.
 Clinical signs observed during exposure included labored respiration, gasping, clear nasal and oral discharge, red ocular discharge, reduced response to sound, and wet fur. Post-exposure, surviving animals exhibited mild-to-moderate initial weight loss, followed by normal weight gain over the 2 week observation period. One animal from the 1.77 mg/l exposure group exhibited lung noise over the entire observation period.

The acute inhalation LC50 of tin tetrachloride (95% confidence limits) was calculated to be 1.35 (1.08-1.77) mg/l.

Applicant's summary and conclusion

Interpretation of results:
not classified
Migrated information Criteria used for interpretation of results: expert judgment
Executive summary:

see endpoint summary