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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According OECD SIDS from 2006

Data source

Reference
Reference Type:
publication
Title:
Irritant and sensitizing potential of copper, mercury, and tin salts in experimental contact stomatitis of rat oral mucosa.
Author:
Larsson, A., B. Kinnby, R. Konsberg, M.J. Peszkowski, and G. Warfvinge
Year:
1990
Bibliographic source:
Contact Dermatitis. 23:146-153

Materials and methods

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
Tin Tetrachloride [CAS No. 7646-78-8]; analytical grade (actual % purity and source not reported).

In vivo test system

Test animals

Details on test animals and environmental conditions:
Animals: Sprague-Dawley rats, 2-3 months old
Vehicle: Alcohol or Alcohol + 0.25% Sodium Lauryl Sulfate (SLS)
Range of concentrations tested: 0.05-20%
Number of animals per test: 2-5
Food/water: standard diet + tap water, ad libitum

Results and discussion

Any other information on results incl. tables

The non-irritant level was defined as the highest level that no tissue damage and/or inflammatory reactions were clearly observed.

Non-irritant level (skin):
SnCl4: 5%
SnCl4 + 0.25% SLS: 5%

Non-irritant level (oral mucosa):
SnCl4: 0.05%
SnCl4 + 0.25% SLS: NA*
* - Not available; inconsistent results were obtained.

The test substance (SnCl4) was determined to be an irritant to oral mucosa at levels >0.05%.
 The combination SnCl4 + 0.25% SLS experiments resulted in no evidence of lymphocytic infiltration. Results of the combined SnCl4/SLS tests gave results similar to tests where 0.25% SLS was applied to the mucosa 1 minute prior to applying the SnCl4 solution.

In the sensitization tests, no reaction could be determined in animals sensitized with 3% SnCl4/SLS, followed by oral elicitation with 0.05% SnCl4.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Executive summary:

According to the above presented data form a publication there is no indication of an sensitizing potential.

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