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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given (Peer reviewed source OECD-SIDS)

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
1973
Reference Type:
secondary source
Title:
p-Toluidine - CAS No: 106-49-0 - SIDS Initial Assessment Report.
Author:
OECD
Year:
2005
Bibliographic source:
UNEP Publications

Materials and methods

Principles of method if other than guideline:
In an inhalation hazard test, 6 rats were exposed for one hour to vapour concentrations of approximately 0.64 mg p-toluidine/L.
GLP compliance:
no
Remarks:
GLP compliance was not mandatory at the time of the study
Test type:
other: Inhalation hazard test
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
p-toluidine
EC Number:
203-403-1
EC Name:
p-toluidine
Cas Number:
106-49-0
Molecular formula:
C7H9N
IUPAC Name:
p-toluidine
Details on test material:
- Name of test material (as cited in study report): p-toluidine
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 188-260 g



Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
other: not reported
Vehicle:
other: air
Details on inhalation exposure:
The test substance was administered as vapour at room temperature. The total air flow was of 10 litre/min.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
0.64 mg/L
No. of animals per sex per dose:
6
Control animals:
other: not applicable
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs, gross pathology

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 0.64 mg/L air
Exp. duration:
1 h
Mortality:
No rat died during and post exposure
Clinical signs:
other: Signs of intoxication started within 0-4 hours and included generalized inactivity, rhinitis and lacrimation, and ceased within one day.
Gross pathology:
Gross autopsy revealed no significant findings

Any other information on results incl. tables

In an inhalation hazard test, 6 rats were exposed for one hour against vapor concentrations of approximately 0.64 mg p-toluidine/L. Signs of intoxication during and post exposure included generalized inactivity, rhinitis and lacrimation, which ceased one day post exposure. No animal died during the exposure or during the 14-day observation period. Gross autopsy revealed no significant findings.

Applicant's summary and conclusion